Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium lyngbya sp. Isolation, stereostructure, and biological activity

Toshiaki Teruya, Hiroaki Sasaki, Hidesuke Fukazawa, Kiyotake Suenaga

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A novel cytotoxic peptide, termed bisebromoamide (1), has been Isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase Inhibition: the phosphorylation of ERK In NRK cells by PDGFstimulation was selectively Inhibited by treatment with 10-0.1 μM of 1.

Original languageEnglish
Pages (from-to)5062-5065
Number of pages4
JournalOrganic Letters
Issue number21
Publication statusPublished - 2009 Nov 5


ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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