Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium lyngbya sp.

Toshiaki Teruya; Hiroaki Sasaki; Kazuhiro Kitamura; Takeshi Nakayama; Kiyotake Suenaga

doi:10.1021/ol900579k

Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium lyngbya sp.

Toshiaki Teruya, Hiroaki Sasaki, Kazuhiro Kitamura, Takeshi Nakayama, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.

Original language	English
Pages (from-to)	2421-2424
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	11
DOIs	https://doi.org/10.1021/ol900579k
Publication status	Published - 2009 Jun 4

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ol900579k

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abstract = "Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.",

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AU - Teruya, Toshiaki

AU - Sasaki, Hiroaki

AU - Kitamura, Kazuhiro

AU - Nakayama, Takeshi

AU - Suenaga, Kiyotake

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N2 - Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.

AB - Bioassay-guided fractionation of the cytotoxic constituents of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyaside (1), a new 18-membered macrolide glycoside. The structure of 1 was established by spectroscopic analysis including 2D-NMR techniques and by synthetic studies. Biselyngbyaside (1) exhibits broad-spectrum cytotoxicity in a human tumor cell line panel.

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Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium lyngbya sp.

Abstract

ASJC Scopus subject areas

UN SDGs

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