Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp.

Osamu Ohno, Ayane Watanabe, Maho Morita, Kiyotake Suenaga

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2DNMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalChemistry Letters
Volume43
Issue number3
DOIs
Publication statusPublished - 2014

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Macrolides
Apoptosis
Cyanobacteria
biselyngbyaside

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp. / Ohno, Osamu; Watanabe, Ayane; Morita, Maho; Suenaga, Kiyotake.

In: Chemistry Letters, Vol. 43, No. 3, 2014, p. 287-289.

Research output: Contribution to journalArticle

Ohno, Osamu ; Watanabe, Ayane ; Morita, Maho ; Suenaga, Kiyotake. / Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp. In: Chemistry Letters. 2014 ; Vol. 43, No. 3. pp. 287-289.
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