Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp.

Osamu Ohno; Ayane Watanabe; Maho Morita; Kiyotake Suenaga

doi:10.1246/cl.130960

Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp.

Osamu Ohno, Ayane Watanabe, Maho Morita, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2DNMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.

Original language	English
Pages (from-to)	287-289
Number of pages	3
Journal	Chemistry Letters
Volume	43
Issue number	3
DOIs	https://doi.org/10.1246/cl.130960
Publication status	Published - 2014

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.130960

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abstract = "A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2DNMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.",

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AU - Ohno, Osamu

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AU - Morita, Maho

AU - Suenaga, Kiyotake

PY - 2014

Y1 - 2014

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AB - A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2DNMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.

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Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp.

Abstract

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