Biselyngbyolide B, a novel ER stress-inducer isolated from the marine cyanobacterium Lyngbya sp.

Osamu Ohno, Ayane Watanabe, Maho Morita, Kiyotake Suenaga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A novel cytotoxic macrolide biselyngbyolide B (1) was isolated from the marine cyanobacterium Lyngbya sp., collected on Ishigaki Island, Japan. The structure of 1 was determined to be the aglycone of biselyngbyaside (2) on the basis of 1D and 2DNMR spectra and CD data. The apoptosis-inducing activity of 1 was 30- to 100-fold greater than that of 2. In addition, 1 was found to exhibit ER stress-inducing activity.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalChemistry Letters
Volume43
Issue number3
DOIs
Publication statusPublished - 2014 Mar 11

ASJC Scopus subject areas

  • Chemistry(all)

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