Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

Arihiro Iwasaki, Takato Tadenuma, Shimpei Sumimoto, Taichi Ohshiro, Kaori Ozaki, Keisuke Kobayashi, Toshiaki Teruya, Hiroshi Tomoda, Kiyotake Suenaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.

Original languageEnglish
Pages (from-to)1161-1166
Number of pages6
JournalJournal of Natural Products
Volume80
Issue number4
DOIs
Publication statusPublished - 2017 Apr 28

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Sterol O-Acyltransferase
Cyanobacteria
Lipopeptides
Cytotoxicity
HeLa Cells
Cells
Degradation
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium. / Iwasaki, Arihiro; Tadenuma, Takato; Sumimoto, Shimpei; Ohshiro, Taichi; Ozaki, Kaori; Kobayashi, Keisuke; Teruya, Toshiaki; Tomoda, Hiroshi; Suenaga, Kiyotake.

In: Journal of Natural Products, Vol. 80, No. 4, 28.04.2017, p. 1161-1166.

Research output: Contribution to journalArticle

Iwasaki, Arihiro ; Tadenuma, Takato ; Sumimoto, Shimpei ; Ohshiro, Taichi ; Ozaki, Kaori ; Kobayashi, Keisuke ; Teruya, Toshiaki ; Tomoda, Hiroshi ; Suenaga, Kiyotake. / Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium. In: Journal of Natural Products. 2017 ; Vol. 80, No. 4. pp. 1161-1166.
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