Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium

Arihiro Iwasaki, Takato Tadenuma, Shimpei Sumimoto, Taichi Ohshiro, Kaori Ozaki, Keisuke Kobayashi, Toshiaki Teruya, Hiroshi Tomoda, Kiyotake Suenaga

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.

Original languageEnglish
Pages (from-to)1161-1166
Number of pages6
JournalJournal of Natural Products
Volume80
Issue number4
DOIs
Publication statusPublished - 2017 Apr 28

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium'. Together they form a unique fingerprint.

  • Cite this