Abstract
We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: (1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T3 ). (2) The effect is mediated through various mechanisms via the thyroid hormone receptor (TRβ1) which is considered to be responsible for OPC differentiation. (3) The action of BPA on OPC differentiation does not involve the FcRγ -Fyn-myelin basic protein (MBP) cascade as an inducer of OPC differentiation nor does it suppress CREB phosphorylation, which is considered to be induced by the T3 -TR complex. (4) The presence of MBP isoforms (21.5, 18.5, 17.0 and 14.0 kDa) was detected in OPCs, and the expression of exon 2-containing isoforms (i.e. 17.0 and 21.5 kDa) was upregulated upon treatment with T3 . In contrast, expression of MBP was inhibited by BPA.
| Original language | English |
|---|---|
| Pages (from-to) | 21-30 |
| Number of pages | 10 |
| Journal | Neuroendocrinology |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2004 |
| Externally published | Yes |
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Keywords
- Bisphenol
- Gonadal hormones
- Mice
- Myelin basic proteins
- Oligodendrocytes
- Selective estrogen receptor modulators
- Thyroid hormone receptors
- Thyroid hormones
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
Cite this
Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells. / Seiwa, Chika; Nakahara, Jin; Komiyama, Takatsugu; Katsu, Yoshinao; Iguchi, Taisen; Asou, Hiroaki.
In: Neuroendocrinology, Vol. 80, No. 1, 2004, p. 21-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells
AU - Seiwa, Chika
AU - Nakahara, Jin
AU - Komiyama, Takatsugu
AU - Katsu, Yoshinao
AU - Iguchi, Taisen
AU - Asou, Hiroaki
PY - 2004
Y1 - 2004
N2 - We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: (1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T3 ). (2) The effect is mediated through various mechanisms via the thyroid hormone receptor (TRβ1) which is considered to be responsible for OPC differentiation. (3) The action of BPA on OPC differentiation does not involve the FcRγ -Fyn-myelin basic protein (MBP) cascade as an inducer of OPC differentiation nor does it suppress CREB phosphorylation, which is considered to be induced by the T3 -TR complex. (4) The presence of MBP isoforms (21.5, 18.5, 17.0 and 14.0 kDa) was detected in OPCs, and the expression of exon 2-containing isoforms (i.e. 17.0 and 21.5 kDa) was upregulated upon treatment with T3 . In contrast, expression of MBP was inhibited by BPA.
AB - We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: (1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T3 ). (2) The effect is mediated through various mechanisms via the thyroid hormone receptor (TRβ1) which is considered to be responsible for OPC differentiation. (3) The action of BPA on OPC differentiation does not involve the FcRγ -Fyn-myelin basic protein (MBP) cascade as an inducer of OPC differentiation nor does it suppress CREB phosphorylation, which is considered to be induced by the T3 -TR complex. (4) The presence of MBP isoforms (21.5, 18.5, 17.0 and 14.0 kDa) was detected in OPCs, and the expression of exon 2-containing isoforms (i.e. 17.0 and 21.5 kDa) was upregulated upon treatment with T3 . In contrast, expression of MBP was inhibited by BPA.
KW - Bisphenol
KW - Gonadal hormones
KW - Mice
KW - Myelin basic proteins
KW - Oligodendrocytes
KW - Selective estrogen receptor modulators
KW - Thyroid hormone receptors
KW - Thyroid hormones
UR - http://www.scopus.com/inward/record.url?scp=5644231983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5644231983&partnerID=8YFLogxK
U2 - 10.1159/000080663
DO - 10.1159/000080663
M3 - Article
C2 - 15345905
AN - SCOPUS:5644231983
VL - 80
SP - 21
EP - 30
JO - Neuroendocrinology
JF - Neuroendocrinology
SN - 0028-3835
IS - 1
ER -