Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS

Tomoo Osumi, Motohiro Kato, Meri Ouchi-Uchiyama, Daisuke Tomizawa, Keisuke Kataoka, Yoichi Fujii, Masafumi Seki, Junko Takita, Seishi Ogawa, Toru Uchiyama, Kentaro Ohki, Nobutaka Kiyokawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.

Original languageEnglish
Article numbere26496
JournalPediatric Blood and Cancer
Volume64
Issue number9
DOIs
Publication statusPublished - 2017 Sep
Externally publishedYes

Keywords

  • blast crisis
  • CNG
  • duplication
  • JMML
  • KRAS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS'. Together they form a unique fingerprint.

Cite this