Blockade of CD28/CTLA4 pathway prevented almost diseases and lymphadenopathy but not lung disease in MRL/lpr mice

Mitsuyoshi Takiguchi, Masaaki Murakami, Izumi Nakagawa, Akira Yamada, Shunsuke Chikuma, Toshimitsu Uede

Research output: Contribution to journalArticle

Abstract

We studied role of CD28/CTLA4 costimulatory T cell activation pathway on the pathogenesis of MRL/lpr mice. Administration of CTLA4IgG inhibited not only autoantibody production and end-organ diseases in kidney, salivary gland and liver but lymphadenopathy, however, lung disease was not inhibited Additional analysis demonstrated that after CTLA4IgG treatment (i) activation of and IL-4 production from conventional T cells, (ii) IFNg production from CD4-CD8-B220+ T cells, and (iii) differentiation from activated B lymphocytes to plasma cells were prevented but (iv) development of CD4-CD8-B220+ T cells and (v) activation of B lymphocytes and macrophage containing fraction was still induced. Thus, we concluded that in MRL/lpr mice CD28/CTLA4 pathway mediated (i) differentiation of conventional T cells to Th2/Tc2-like cells, (ii) differentiation of B cells to plasma cells, (iii) IFNg production from CD4-CD8-B220+ T cells and (iv) accumulation of lymphoid cell populations however, (v) development of CD4-CD8-B220+ T cells and (vi) activation of B lymphocytes and macrophages were not mediated by CD28/CTLA4 pathway.

Original languageEnglish
JournalFASEB Journal
Volume12
Issue number5
Publication statusPublished - 1998 Mar 20
Externally publishedYes

Fingerprint

Inbred MRL lpr Mouse
lymphatic diseases
Pulmonary diseases
T-cells
respiratory tract diseases
Lung Diseases
T-lymphocytes
T-Lymphocytes
mice
B-lymphocytes
Lymphocytes
B-Lymphocytes
Chemical activation
Macrophage Activation
Macrophages
plasma cells
Plasma Cells
Cell Differentiation
macrophages
Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Blockade of CD28/CTLA4 pathway prevented almost diseases and lymphadenopathy but not lung disease in MRL/lpr mice. / Takiguchi, Mitsuyoshi; Murakami, Masaaki; Nakagawa, Izumi; Yamada, Akira; Chikuma, Shunsuke; Uede, Toshimitsu.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Takiguchi, Mitsuyoshi ; Murakami, Masaaki ; Nakagawa, Izumi ; Yamada, Akira ; Chikuma, Shunsuke ; Uede, Toshimitsu. / Blockade of CD28/CTLA4 pathway prevented almost diseases and lymphadenopathy but not lung disease in MRL/lpr mice. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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