Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells

Iyuki Namekata, Noriko Tsuruoka, Yayoi Tsuneoka, Tomoyuki Matsuda, Akira Takahara, Yoshio Tanaka, Takeshi Suzuki, Tetsuo Takahashi, Naoko Iida-Tanaka, Hikaru Tanaka

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Abstract

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume34
Issue number1
DOIs
Publication statusPublished - 2011 Jan 28
Externally publishedYes

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Keywords

  • Atrial fibrillation
  • KCNE1
  • KCNQ1
  • NIP-142

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Namekata, I., Tsuruoka, N., Tsuneoka, Y., Matsuda, T., Takahara, A., Tanaka, Y., Suzuki, T., Takahashi, T., Iida-Tanaka, N., & Tanaka, H. (2011). Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. Biological and Pharmaceutical Bulletin, 34(1), 153-155. https://doi.org/10.1248/bpb.34.153