Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells

Iyuki Namekata, Noriko Tsuruoka, Yayoi Tsuneoka, Tomoyuki Matsuda, Akira Takahara, Yoshio Tanaka, Takeshi Suzuki, Tetsuo Takahashi, Naoko Iida-Tanaka, Hikaru Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume34
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

HEK293 Cells
Delayed Rectifier Potassium Channels
Benzopyrans
Cardiac Arrhythmias
NIP142
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane

Keywords

  • Atrial fibrillation
  • KCNE1
  • KCNQ1
  • NIP-142

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Namekata, I., Tsuruoka, N., Tsuneoka, Y., Matsuda, T., Takahara, A., Tanaka, Y., ... Tanaka, H. (2011). Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. Biological and Pharmaceutical Bulletin, 34(1), 153-155. https://doi.org/10.1248/bpb.34.153

Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. / Namekata, Iyuki; Tsuruoka, Noriko; Tsuneoka, Yayoi; Matsuda, Tomoyuki; Takahara, Akira; Tanaka, Yoshio; Suzuki, Takeshi; Takahashi, Tetsuo; Iida-Tanaka, Naoko; Tanaka, Hikaru.

In: Biological and Pharmaceutical Bulletin, Vol. 34, No. 1, 2011, p. 153-155.

Research output: Contribution to journalArticle

Namekata, I, Tsuruoka, N, Tsuneoka, Y, Matsuda, T, Takahara, A, Tanaka, Y, Suzuki, T, Takahashi, T, Iida-Tanaka, N & Tanaka, H 2011, 'Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells', Biological and Pharmaceutical Bulletin, vol. 34, no. 1, pp. 153-155. https://doi.org/10.1248/bpb.34.153
Namekata, Iyuki ; Tsuruoka, Noriko ; Tsuneoka, Yayoi ; Matsuda, Tomoyuki ; Takahara, Akira ; Tanaka, Yoshio ; Suzuki, Takeshi ; Takahashi, Tetsuo ; Iida-Tanaka, Naoko ; Tanaka, Hikaru. / Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells. In: Biological and Pharmaceutical Bulletin. 2011 ; Vol. 34, No. 1. pp. 153-155.
@article{baa11799f5a64a92831b4ef9b5d9461b,
title = "Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells",
abstract = "We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.",
keywords = "Atrial fibrillation, KCNE1, KCNQ1, NIP-142",
author = "Iyuki Namekata and Noriko Tsuruoka and Yayoi Tsuneoka and Tomoyuki Matsuda and Akira Takahara and Yoshio Tanaka and Takeshi Suzuki and Tetsuo Takahashi and Naoko Iida-Tanaka and Hikaru Tanaka",
year = "2011",
doi = "10.1248/bpb.34.153",
language = "English",
volume = "34",
pages = "153--155",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "1",

}

TY - JOUR

T1 - Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells

AU - Namekata, Iyuki

AU - Tsuruoka, Noriko

AU - Tsuneoka, Yayoi

AU - Matsuda, Tomoyuki

AU - Takahara, Akira

AU - Tanaka, Yoshio

AU - Suzuki, Takeshi

AU - Takahashi, Tetsuo

AU - Iida-Tanaka, Naoko

AU - Tanaka, Hikaru

PY - 2011

Y1 - 2011

N2 - We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

AB - We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

KW - Atrial fibrillation

KW - KCNE1

KW - KCNQ1

KW - NIP-142

UR - http://www.scopus.com/inward/record.url?scp=78951475030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78951475030&partnerID=8YFLogxK

U2 - 10.1248/bpb.34.153

DO - 10.1248/bpb.34.153

M3 - Article

C2 - 21212535

AN - SCOPUS:78951475030

VL - 34

SP - 153

EP - 155

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 1

ER -