Blood-direct InvaderPlus® as a new method for genetic testing

Akira Hirasawa, Tomoko Akahane, Yusuke Tanigawara, Daisuke Aoki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: This study compared the efficiency of Blood-direct InvaderPlus® with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. Materials & methods: We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. Results: The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A16,27,28,60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C92 and3 much faster than the conventional methods. Conclusion: Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalPersonalized Medicine
Volume9
Issue number6
DOIs
Publication statusPublished - 2012 Aug

Fingerprint

Genetic Testing
Genetic Polymorphisms
Genes

Keywords

  • CYP2C9
  • genetic testing
  • InvaderPlus®
  • pharmacogenomics
  • UGT1A1
  • VKORC1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Medicine(all)

Cite this

Blood-direct InvaderPlus® as a new method for genetic testing. / Hirasawa, Akira; Akahane, Tomoko; Tanigawara, Yusuke; Aoki, Daisuke.

In: Personalized Medicine, Vol. 9, No. 6, 08.2012, p. 657-663.

Research output: Contribution to journalArticle

@article{e8ce652221ad4082ae65d271f707966b,
title = "Blood-direct InvaderPlus{\circledR} as a new method for genetic testing",
abstract = "Aim: This study compared the efficiency of Blood-direct InvaderPlus{\circledR} with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. Materials & methods: We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. Results: The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A16,27,28,60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C92 and3 much faster than the conventional methods. Conclusion: Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.",
keywords = "CYP2C9, genetic testing, InvaderPlus{\circledR}, pharmacogenomics, UGT1A1, VKORC1",
author = "Akira Hirasawa and Tomoko Akahane and Yusuke Tanigawara and Daisuke Aoki",
year = "2012",
month = "8",
doi = "10.2217/pme.12.71",
language = "English",
volume = "9",
pages = "657--663",
journal = "Personalized Medicine",
issn = "1741-0541",
publisher = "Future Medicine Ltd.",
number = "6",

}

TY - JOUR

T1 - Blood-direct InvaderPlus® as a new method for genetic testing

AU - Hirasawa, Akira

AU - Akahane, Tomoko

AU - Tanigawara, Yusuke

AU - Aoki, Daisuke

PY - 2012/8

Y1 - 2012/8

N2 - Aim: This study compared the efficiency of Blood-direct InvaderPlus® with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. Materials & methods: We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. Results: The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A16,27,28,60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C92 and3 much faster than the conventional methods. Conclusion: Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.

AB - Aim: This study compared the efficiency of Blood-direct InvaderPlus® with existing methods for detecting genetic polymorphisms by using clinical samples, and to determine whether this new method can be used for future clinical studies. Materials & methods: We developed a new method, called Blood-direct InvaderPlus, for detecting genetic polymorphisms. Whole-blood samples were subjected to genetic analysis with the new method and also the conventional method. Results: The results obtained with the new method were consistent with those of direct sequencing. Blood-direct InvaderPlus was able to detect gene polymorphisms of UGT1A16,27,28,60, VKORC1 -1639G>A, VKORC1 1173T>C and CYP2C92 and3 much faster than the conventional methods. Conclusion: Blood-direct InvaderPlus allowed accurate, simple and rapid detection of genetic polymorphisms.

KW - CYP2C9

KW - genetic testing

KW - InvaderPlus®

KW - pharmacogenomics

KW - UGT1A1

KW - VKORC1

UR - http://www.scopus.com/inward/record.url?scp=84865506667&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865506667&partnerID=8YFLogxK

U2 - 10.2217/pme.12.71

DO - 10.2217/pme.12.71

M3 - Article

VL - 9

SP - 657

EP - 663

JO - Personalized Medicine

JF - Personalized Medicine

SN - 1741-0541

IS - 6

ER -