Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants

the Japan Environment and Children’s Study (JECS)

the Japan Environment and Children’s Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl −1 , 3.83 (2.70–5.43) µg l −1 , 0.70 (0.52–0.95) µg l −1 , 16.1 (13.2–19.6) µg l −1 and 178 (165–192) µg l −1 , respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

Original languageEnglish
JournalJournal of Exposure Science and Environmental Epidemiology
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Mercury (metal)
Selenium
Manganese
Mercury
Cadmium
Pregnant Women
Japan
Blood
Lead
Maternal Age
Child Development
Cohort Studies
Inductively coupled plasma mass spectrometry
Beverages
Fish
Gestational Age
Blood Proteins
Mass Spectrometry
Fishes
Smoking

Keywords

  • Birth cohort
  • Cadmium
  • Japan Environment and Children’s Study (JECS)
  • Lead
  • Manganese
  • Mercury

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

Cite this

@article{c49a6eeb2f744e96ba6e1e056396c170,
title = "Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)",
abstract = "The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl −1 , 3.83 (2.70–5.43) µg l −1 , 0.70 (0.52–0.95) µg l −1 , 16.1 (13.2–19.6) µg l −1 and 178 (165–192) µg l −1 , respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.",
keywords = "Birth cohort, Cadmium, Japan Environment and Children’s Study (JECS), Lead, Manganese, Mercury",
author = "{the Japan Environment and Children’s Study Group} and Nakayama, {Shoji F.} and Miyuki Iwai-Shimada and Tomoko Oguri and Tomohiko Isobe and Ayano Takeuchi and Yayoi Kobayashi and Takehiro Michikawa and Shin Yamazaki and Hiroshi Nitta and Toshihiro Kawamoto and Hirohisa Saito and Reiko Kishi and Nobuo Yaegashi and Koichi Hashimoto and Chisato Mori and Shuichi Ito and Zentaro Yamagata and Hidekuni Inadera and Michihiro Kamijima and Takeo Nakayama and Hiroyasu Iso and Masayuki Shima and Yasuaki Hirooka and Narufumi Suganuma and Koichi Kusuhara and Takahiko Katoh",
year = "2019",
month = "1",
day = "1",
doi = "10.1038/s41370-019-0139-0",
language = "English",
journal = "Journal of Exposure Science and Environmental Epidemiology",
issn = "1559-0631",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants

T2 - the Japan Environment and Children’s Study (JECS)

AU - the Japan Environment and Children’s Study Group

AU - Nakayama, Shoji F.

AU - Iwai-Shimada, Miyuki

AU - Oguri, Tomoko

AU - Isobe, Tomohiko

AU - Takeuchi, Ayano

AU - Kobayashi, Yayoi

AU - Michikawa, Takehiro

AU - Yamazaki, Shin

AU - Nitta, Hiroshi

AU - Kawamoto, Toshihiro

AU - Saito, Hirohisa

AU - Kishi, Reiko

AU - Yaegashi, Nobuo

AU - Hashimoto, Koichi

AU - Mori, Chisato

AU - Ito, Shuichi

AU - Yamagata, Zentaro

AU - Inadera, Hidekuni

AU - Kamijima, Michihiro

AU - Nakayama, Takeo

AU - Iso, Hiroyasu

AU - Shima, Masayuki

AU - Hirooka, Yasuaki

AU - Suganuma, Narufumi

AU - Kusuhara, Koichi

AU - Katoh, Takahiko

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl −1 , 3.83 (2.70–5.43) µg l −1 , 0.70 (0.52–0.95) µg l −1 , 16.1 (13.2–19.6) µg l −1 and 178 (165–192) µg l −1 , respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

AB - The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl −1 , 3.83 (2.70–5.43) µg l −1 , 0.70 (0.52–0.95) µg l −1 , 16.1 (13.2–19.6) µg l −1 and 178 (165–192) µg l −1 , respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

KW - Birth cohort

KW - Cadmium

KW - Japan Environment and Children’s Study (JECS)

KW - Lead

KW - Manganese

KW - Mercury

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U2 - 10.1038/s41370-019-0139-0

DO - 10.1038/s41370-019-0139-0

M3 - Article

JO - Journal of Exposure Science and Environmental Epidemiology

JF - Journal of Exposure Science and Environmental Epidemiology

SN - 1559-0631

ER -