Blood Oxygen Sensor Using a Boron-Doped Diamond Electrode

Yunita Triana, Genki Ogata, Mai Tomisaki, Irkham, Yasuaki Einaga

Research output: Contribution to journalArticlepeer-review

Abstract

The electrochemical behavior of oxygen (O2) in blood was studied using boron-doped diamond (BDD) electrodes. Cyclic voltammogram of O2 in a 0.1 M phosphate buffer solution solution containing 1 × 10-6 M of bovine hemoglobin exhibits a reduction peak at -1.4 V (vs Ag/AgCl). Moreover, the scan rate dependence was investigated to study the reduction reaction mechanism, which was attributable to the reduction of O2 to H2O2 via two electrons. A linear calibration curve was observed in the concentration range of 86.88-314.63 mg L-1 (R2 = 0.99) with a detection limit of 1.0 mg L-1 (S/B = 3). The analytical performance was better than those with glassy carbon or platinum electrodes as the working electrode. In addition, an application to bovine blood was performed. The O2 concentration in the blood measured on the BDD electrodes was compared to that measured using an OxyLite Pro fiber-optic oxygen sensor device. Both methods gave similar values of the O2 concentration in the range of ∼40 to 150 mmHg. This result confirms that BDD electrodes could potentially be used to detect the O2 concentration in blood.

Original languageEnglish
Pages (from-to)3948-3955
Number of pages8
JournalAnalytical Chemistry
Volume94
Issue number9
DOIs
Publication statusPublished - 2022 Mar 8
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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