Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Kenta Gonokami, Taku Obara, Mitsuru Kobayashi, Sakiko Katada, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

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Abstract

The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalClinical and Experimental Hypertension
Volume32
Issue number5
DOIs
Publication statusPublished - 2010 Aug

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Keywords

  • Doxazosin
  • Home blood pressure (HBP)
  • Morning hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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