Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status

Akiko Hanyuda, Yin Cao, Tsuyoshi Hamada, Jonathan A. Nowak, Zhi Rong Qian, Yohei Masugi, Annacarolina da Silva, Li Liu, Keisuke Kosumi, Thing Rinda Soong, Iny Jhun, Kana Wu, Xuehong Zhang, Mingyang Song, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Edward L. Giovannucci, Shuji Ogino, Reiko Nishihara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Previous studies suggest that abnormal energy balance status may dysregulate intestinal epithelial homeostasis and promote colorectal carcinogenesis, yet little is known about how host energy balance and obesity influence enterocyte differentiation during carcinogenesis. We hypothesized that the association between high body mass index (BMI) and colorectal carcinoma incidence might differ according to tumor histopathologic differentiation status. Using databases of the Nurses’ Health Study and Health Professionals Follow-up Study, and duplication-method Cox proportional hazards models, we prospectively examined an association between BMI and the incidence of colorectal carcinoma subtypes classified by differentiation features. 120,813 participants were followed for 26 or 32 years and 1528 rectal and colon cancer cases with available tumor pathological data were documented. The association between BMI and colorectal cancer risk significantly differed depending on the presence or absence of poorly-differentiated foci (Pheterogeneity = 0.006). Higher BMI was associated with a higher risk of colorectal carcinoma without poorly-differentiated foci (≥30.0 vs. 18.5–22.4 kg/m2: multivariable-adjusted hazard ratio, 1.87; 95% confidence interval, 1.49–2.34; Ptrend < 0.001), but not with risk of carcinoma with poorly-differentiated foci (Ptrend = 0.56). This differential association appeared to be consistent in strata of tumor microsatellite instability or FASN expression status, although the statistical power was limited. The association between BMI and colorectal carcinoma risk did not significantly differ by overall tumor differentiation, mucinous differentiation, or signet ring cell component (Pheterogeneity > 0.03, with the adjusted α of 0.01). High BMI was associated with risk of colorectal cancer subtype containing no poorly-differentiated focus. Our findings suggest that carcinogenic influence of excess energy balance might be stronger for tumors that retain better intestinal differentiation throughout the tumor areas.

Original languageEnglish
Pages (from-to)393-407
Number of pages15
JournalEuropean Journal of Epidemiology
Volume32
Issue number5
DOIs
Publication statusPublished - 2017 May 1
Externally publishedYes

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Colorectal Neoplasms
Body Mass Index
Neoplasms
Carcinogenesis
Enterocytes
Incidence
Health
Rectal Neoplasms
Proportional Hazards Models
Colonic Neoplasms
Homeostasis
Obesity
Nurses
Databases
Confidence Intervals

Keywords

  • Epigenetics
  • Glandular epithelium
  • Metabolism
  • Molecular pathological epidemiology
  • Overweight
  • Stem cell

ASJC Scopus subject areas

  • Epidemiology

Cite this

Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. / Hanyuda, Akiko; Cao, Yin; Hamada, Tsuyoshi; Nowak, Jonathan A.; Qian, Zhi Rong; Masugi, Yohei; da Silva, Annacarolina; Liu, Li; Kosumi, Keisuke; Soong, Thing Rinda; Jhun, Iny; Wu, Kana; Zhang, Xuehong; Song, Mingyang; Meyerhardt, Jeffrey A.; Chan, Andrew T.; Fuchs, Charles S.; Giovannucci, Edward L.; Ogino, Shuji; Nishihara, Reiko.

In: European Journal of Epidemiology, Vol. 32, No. 5, 01.05.2017, p. 393-407.

Research output: Contribution to journalArticle

Hanyuda, A, Cao, Y, Hamada, T, Nowak, JA, Qian, ZR, Masugi, Y, da Silva, A, Liu, L, Kosumi, K, Soong, TR, Jhun, I, Wu, K, Zhang, X, Song, M, Meyerhardt, JA, Chan, AT, Fuchs, CS, Giovannucci, EL, Ogino, S & Nishihara, R 2017, 'Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status', European Journal of Epidemiology, vol. 32, no. 5, pp. 393-407. https://doi.org/10.1007/s10654-017-0254-y
Hanyuda, Akiko ; Cao, Yin ; Hamada, Tsuyoshi ; Nowak, Jonathan A. ; Qian, Zhi Rong ; Masugi, Yohei ; da Silva, Annacarolina ; Liu, Li ; Kosumi, Keisuke ; Soong, Thing Rinda ; Jhun, Iny ; Wu, Kana ; Zhang, Xuehong ; Song, Mingyang ; Meyerhardt, Jeffrey A. ; Chan, Andrew T. ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Ogino, Shuji ; Nishihara, Reiko. / Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. In: European Journal of Epidemiology. 2017 ; Vol. 32, No. 5. pp. 393-407.
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