Body mass index and risk of stroke mortality among a random sample of Japanese adults: 19-Year follow-up of NIPPON DATA80

Izumi Oki, Yosikazu Nakamura, Tomonori Okamura, Akira Okayama, Takehito Hayakawa, Yoshikuni Kita, Hirotsugu Ueshima, Osamu Iimura, Teruo Omae, Kazuo Ueda, Hiroshi Yanagawa, Hiroshi Horibe, Kazunori Kodama, Fumlyoshi Kasagi, Shinichi Tanihara, Shigeyuki Saito, Kiyomi Sakata, Fumihiko Kakuno, Toshihiro Takeuchi, Mitsuru HasebeFumitsugu Kusano, Takahisa Kawamoto, Masumi Minowa, Katsuhiko Kawaminami, Sohel R. Choudhury, Yutaka Kiyohara, Minoru Iida, Tsutomu Hashimoto, Atsushi Terao, Koryo Sawai, Shigeo Shibata

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: The relationship between body mass index (BMI) and stroke mortality remains unclear. The aim of the present study was to elucidate the relationship between BMI and stroke death in a representative cohort of Japanese men and women. Methods: We analyzed a database of 9,526 men and women aged 30 years and older who were randomly selected throughout Japan in 1980. These individuals had no history of stroke and were followed for 19 years. Hazard ratios (HR) and their 95% confidence intervals (CI) of deaths due to total stroke, cerebral infarction, and intracerebral hemorrhage were examined using Cox's proportional hazards regression models of BMI levels. Results: A U-shaped association between BMI and cerebral infarction mortality was observed. Participants with the highest BMI category (BMI ≥ 30.0) showed a significantly highest HR for cerebral infarction (HR 2.46, 95% CI 1.01-5.99). The excess risk at the lower extreme of the BMI was confined to men. These associations did not change after excluding deaths occurring in the first 2 years of follow-up. Conclusions: In the Japanese general population, a U-shaped association between BMI and cerebral infarction mortality was found and the excess risk at the lower extreme of the BMI was confined to men.

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalCerebrovascular Diseases
Volume22
Issue number5-6
DOIs
Publication statusPublished - 2006 Oct 1
Externally publishedYes

Keywords

  • Body mass index
  • Cerebral infarction
  • Intracerebral hemorrhage
  • Obesity
  • Stroke mortality

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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    Oki, I., Nakamura, Y., Okamura, T., Okayama, A., Hayakawa, T., Kita, Y., Ueshima, H., Iimura, O., Omae, T., Ueda, K., Yanagawa, H., Horibe, H., Kodama, K., Kasagi, F., Tanihara, S., Saito, S., Sakata, K., Kakuno, F., Takeuchi, T., ... Shibata, S. (2006). Body mass index and risk of stroke mortality among a random sample of Japanese adults: 19-Year follow-up of NIPPON DATA80. Cerebrovascular Diseases, 22(5-6), 409-415. https://doi.org/10.1159/000094860