Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity

Utpal K. Karmakar; Midori A. Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.1016/j.tetlet.2017.08.055

Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity

Utpal K. Karmakar, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.

Original language	English
Pages (from-to)	3838-3841
Number of pages	4
Journal	Tetrahedron Letters
Volume	58
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2017.08.055
Publication status	Published - 2017 Jan 1
Externally published	Yes

Keywords

Boesenbergia pandurata
Isopimarane diterpenes
TRAIL-resistance

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity",

abstract = "TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.",

keywords = "Boesenbergia pandurata, Isopimarane diterpenes, TRAIL-resistance",

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AU - Karmakar, Utpal K.

AU - Arai, Midori A.

AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Ishibashi, Masami

PY - 2017/1/1

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