TY - JOUR
T1 - Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity
AU - Karmakar, Utpal K.
AU - Arai, Midori A.
AU - Koyano, Takashi
AU - Kowithayakorn, Thaworn
AU - Ishibashi, Masami
N1 - Funding Information:
This work was supported by JSPS Kakenhi grant numbers JP26305001 and JP17H03992 , and the Strategic Priority Research Promotion Program of Chiba University ”Phytochemical Plant Molecular Sciences”. A
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017
Y1 - 2017
N2 - TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.
AB - TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.
KW - Boesenbergia pandurata
KW - Isopimarane diterpenes
KW - TRAIL-resistance
UR - http://www.scopus.com/inward/record.url?scp=85028502960&partnerID=8YFLogxK
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U2 - 10.1016/j.tetlet.2017.08.055
DO - 10.1016/j.tetlet.2017.08.055
M3 - Article
AN - SCOPUS:85028502960
VL - 58
SP - 3838
EP - 3841
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 40
ER -
