Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity

Utpal K. Karmakar, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.

Original languageEnglish
Pages (from-to)3838-3841
Number of pages4
JournalTetrahedron Letters
Volume58
Issue number40
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Keywords

  • Boesenbergia pandurata
  • Isopimarane diterpenes
  • TRAIL-resistance

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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