[Bone and Stem Cells. Regulation of haematopoietic stem cell maintenance and mobilization by osteoclasts].

Takeshi Miyamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Haematopoietic stem cells (HSCs) are maintained in a specialized microenvironment termed "niche" in bone marrow (BM) cavities. Osteoclasts are required for formation of BM cavities, and thus, osteoclast-less animals exhibit BM cavity-less osteopetrotic phenotypes. Osteoclasts were also reportedly required for mobilization of haematopoietic stem and progenitor cells (HSPCs) to the periphery from BM cavities, however, how HSCs are maintained and HSPC mobilization is regulated in osteoclast-less animals were largely unknown. In this review, roles of osteoclasts in HSC maintenance and HSPC mobilization are discussed.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalClinical calcium
Volume24
Issue number4
Publication statusPublished - 2014

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Hematopoietic Stem Cell Mobilization
Osteoclasts
Hematopoietic Stem Cells
Stem Cells
Maintenance
Bone and Bones
Bone Marrow
Phenotype

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Bone and Stem Cells. Regulation of haematopoietic stem cell maintenance and mobilization by osteoclasts]. / Miyamoto, Takeshi.

In: Clinical calcium, Vol. 24, No. 4, 2014, p. 527-531.

Research output: Contribution to journalArticle

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