Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn

Hiroshi Yagi, Alejandro Soto-Gutierrez, Yuko Kitagawa, Arno W. Tilles, Ronald G. Tompkins, Martin L. Yarmush

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

Bone marrow mesenchymal stromal cells (MSCs) suppress immune cell responses and have beneficial effects in various inflammatory-related immune disorders. A therapeutic modality for systemic inflammation and its consequences is not available yet. Thus, this work investigates the therapeutic effects of MSCs in injury models induced by lipopolysaccharide (LPS) or burn. Gene expression was analyzed in MSCs when exposed to inflammatory serum from injured animals and it showed remarkable alterations compared to normal culture. In addition, injured animals were transplanted intramuscularly with MSCs. Forty-eight hours after cell transplantation, kidney, lung, and liver were analyzed for infiltration of inflammatory cells and TUNEL-expressing cells. Results showed that MSCs attenuate injury by reducing the infiltration of inflammatory cells in various target organs and by reducing cell death. These data suggest that MSCs emerge as key regulators of immune/inflammatory responses in vivo and as attractive candidates for cell-based treatments for systemic inflammatory-based disorders.

Original languageEnglish
Pages (from-to)823-830
Number of pages8
JournalCell Transplantation
Volume19
Issue number6-7
DOIs
Publication statusPublished - 2010

Keywords

  • Anti-inflammation
  • Antiapoptosis
  • Burn
  • Lipopolysaccharide (LPS)
  • Multiple organ injury
  • Sepsis
  • Systemic inflammatory response syndrome (SIRS)

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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