Bone quality and vitamin K2 in type 2 diabetes: Review of preclinical and clinical studies

Jun Iwamoto, Yoshihiro Sato, Tsuyoshi Takeda, Hideo Matsumoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Type 2 diabetic patients are at high risk of bone fractures even if their bone mineral density is normal or high. This is likely explained by poor bone quality and extraskeletal factors. The present review was conducted to provide an overview of the currently available preclinical and clinical evidence on the effect of vitamin K2 on bone quality in persons with type 2 diabetes. Vitamin K2 stimulates γ-carboxylation of osteocalcin and can increase bone formation through steroid and xenobiotic receptors. Clinical studies of type 2 diabetic patients have shown detrimental collagen cross-links in bone; low serum insulin-like growth factor-I and osteocalcin concentration are associated with an increased risk of fractures. A therapeutic strategy for preventing fractures in type 2 diabetic patients remains to be established. One recent preclinical study showed that vitamin K2 administration in a type 2 diabetic rat model had the following skeletal benefits: increased serum osteocalcin, improved collagen cross-link profiles, and increased bone strength. These new findings suggesting a possible beneficial effect of vitamin K2 supplementation on bone quality in type 2 diabetes warrant further investigation.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalNutrition Reviews
Volume69
Issue number3
DOIs
Publication statusPublished - 2011 Mar 1

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Keywords

  • Bone fracture
  • Bone mineral density
  • Bone quality
  • Type 2 diabetes
  • Vitamin K

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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