Bone turnover and bone structure in clinical animal models of COPD

Mamoru Sasaki, Shotaro Chubachi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The features of chronic obstructive pulmonary disease(COPD)are chronic inflammatory and emphysema changes in the lungs by long-term cigarette smoke(CS)exposure. Osteoporosis is an important systemic comorbidity of COPD. Severe emphysema and low body mass index(BMI)are independent risk factors for low bone mineral density in COPD patients. However the pathophysiologic mechanisms underlying emphysema and osteoporosis have not been fully elucidated. An established mouse model of CS-induced emphysema with decrease body weight and bone mineral density is important for investigating the cause of osteoporosis in COPD patients.

Original languageEnglish
Pages (from-to)1413-1418
Number of pages6
JournalClinical calcium
Volume26
Issue number10
Publication statusPublished - 2016 Jan 1

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Bone Remodeling
Emphysema
Chronic Obstructive Pulmonary Disease
Animal Models
Osteoporosis
Bone and Bones
Smoke
Tobacco Products
Bone Density
Comorbidity
Body Mass Index
Body Weight
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bone turnover and bone structure in clinical animal models of COPD. / Sasaki, Mamoru; Chubachi, Shotaro.

In: Clinical calcium, Vol. 26, No. 10, 01.01.2016, p. 1413-1418.

Research output: Contribution to journalReview article

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