Abstract
Aim: Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD. Methods: CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with brain magnetic resonance imaging (MRI), and carotid/intracranial artery magnetic resonance angiography (MRA) in 44 pre-dialytic patients. The severity of CVD was evaluated by the number of lacunes and the degree of stenosis, respectively. The association between CVD and atherosclerotic parameters was evaluated. Results: Patients with severe lacunes (n = 18) manifested older age, lower diastolic blood pressure, serum creatinine and albumin, and higher CRP and serum calcium than those with absent-moderate lacunes (n = 26). When assessed by multivariate analysis, only baPWV was adopted as an independent risk factor for severe lacunes. Furthermore, baPWV and i-PTH were associated with the severity of carotid/intracranial artery stenosis, both of which were independent of other risk factors, including age and diabetes. Conclusions: Arterial stiffness may constitute a novel determinant predicting the severity of CVD in pre-dialytic patients besides classical risk factors.
Original language | English |
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Pages (from-to) | 165-172 |
Number of pages | 8 |
Journal | Journal of atherosclerosis and thrombosis |
Volume | 17 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- Carotid/intracranial artery stenosis
- End-stage renal disease
- Lacunar infarction
- Malnutrition-inflammation-atherosclerosis syndrome
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
- Biochemistry, medical