Brain regional pharmacokinetics of biperiden in rats

K. Yokogawa, E. Nakashima, J. Ishizaki, M. Hasegawa, H. Kido, F. Ichimura

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The pharmacokinetic profiles of biperiden (BP) in blood and in specific brain regions were investigated in rats after acute i.v. administration. The regional brain-to-blood unbound concentration ratios (K(pf)) were also determined after 16 h intravenous infusion of BP. The K(pf) values ranged from 30 to 75 in the different brain regions and showed decreasing concentrations in the following order: pons + medulla oblongata, basal ganglia, amygdala, hypothalamus, thalamus, mesencephalon, bulbus olfactorius + septum, hippocampus, frontal cortex, occipital cortex, cerebellum. The relationship between BP and acetylcholine (ACh) concentrations in the brain regions was examined. ACh levels in the various brain regions ranged from 8 to 44 ng g-1 tissue. There was a significant correlation between the K(pf) values of BP and the levels of ACh in the brain regions except for the pons + oblongata. BP concentrations in the brain regions after BP administration were predicted based on the physiological pharmacokinetics. There was reasonable agreement between the model predictions and the observed data.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalBiopharmaceutics and Drug Disposition
Volume13
Issue number2
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Biperiden
Pharmacokinetics
Brain
Acetylcholine
Pons
Occipital Lobe
Medulla Oblongata
Olfactory Bulb
Frontal Lobe
Mesencephalon
Amygdala
Basal Ganglia
Thalamus
Intravenous Infusions
Cerebellum
Hypothalamus
Hippocampus

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Yokogawa, K., Nakashima, E., Ishizaki, J., Hasegawa, M., Kido, H., & Ichimura, F. (1992). Brain regional pharmacokinetics of biperiden in rats. Biopharmaceutics and Drug Disposition, 13(2), 131-140.

Brain regional pharmacokinetics of biperiden in rats. / Yokogawa, K.; Nakashima, E.; Ishizaki, J.; Hasegawa, M.; Kido, H.; Ichimura, F.

In: Biopharmaceutics and Drug Disposition, Vol. 13, No. 2, 1992, p. 131-140.

Research output: Contribution to journalArticle

Yokogawa, K, Nakashima, E, Ishizaki, J, Hasegawa, M, Kido, H & Ichimura, F 1992, 'Brain regional pharmacokinetics of biperiden in rats', Biopharmaceutics and Drug Disposition, vol. 13, no. 2, pp. 131-140.
Yokogawa K, Nakashima E, Ishizaki J, Hasegawa M, Kido H, Ichimura F. Brain regional pharmacokinetics of biperiden in rats. Biopharmaceutics and Drug Disposition. 1992;13(2):131-140.
Yokogawa, K. ; Nakashima, E. ; Ishizaki, J. ; Hasegawa, M. ; Kido, H. ; Ichimura, F. / Brain regional pharmacokinetics of biperiden in rats. In: Biopharmaceutics and Drug Disposition. 1992 ; Vol. 13, No. 2. pp. 131-140.
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