Brain renin-angiotensin: Central control of secretion of atrial natriuretic factor from the heart

Hiroshi Itoh, Kazuwa Nakao, Takayuki Yamada, Narito Morii, Shozo Shiono, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Hiroo Imura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To elucidate the modulatory role of the brain renln-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 fig significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 ± 57 pg/ml; angiotensin II 100 ng, 1110 ± 320 pg/ml, p < 0.01; angiotensin II 1μg, 1055 ± 60 pg/ml, p < 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin H-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V<inf>1</inf>-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renln-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central α-adrenergic neural pathway.

Original languageEnglish
Pages (from-to)I-57-I-61
JournalHypertension
Volume11
Issue number2
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Angiotensins
Atrial Natriuretic Factor
Renin
Angiotensin II
Brain
Ficus
Neural Pathways
Phentolamine
Vasopressins
Adrenergic Agents

Keywords

  • Blood pressure
  • Body fluid homeostasis
  • Central nervous system
  • V<inf>1</inf> receptor
  • Vasopressin
  • Volume expansion
  • α-adrenergic system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Itoh, H., Nakao, K., Yamada, T., Morii, N., Shiono, S., Sugawara, A., ... Imura, H. (1988). Brain renin-angiotensin: Central control of secretion of atrial natriuretic factor from the heart. Hypertension, 11(2), I-57-I-61.

Brain renin-angiotensin : Central control of secretion of atrial natriuretic factor from the heart. / Itoh, Hiroshi; Nakao, Kazuwa; Yamada, Takayuki; Morii, Narito; Shiono, Shozo; Sugawara, Akira; Saito, Yoshihiko; Mukoyama, Masashi; Arai, Hiroshi; Imura, Hiroo.

In: Hypertension, Vol. 11, No. 2, 1988, p. I-57-I-61.

Research output: Contribution to journalArticle

Itoh, H, Nakao, K, Yamada, T, Morii, N, Shiono, S, Sugawara, A, Saito, Y, Mukoyama, M, Arai, H & Imura, H 1988, 'Brain renin-angiotensin: Central control of secretion of atrial natriuretic factor from the heart', Hypertension, vol. 11, no. 2, pp. I-57-I-61.
Itoh H, Nakao K, Yamada T, Morii N, Shiono S, Sugawara A et al. Brain renin-angiotensin: Central control of secretion of atrial natriuretic factor from the heart. Hypertension. 1988;11(2):I-57-I-61.
Itoh, Hiroshi ; Nakao, Kazuwa ; Yamada, Takayuki ; Morii, Narito ; Shiono, Shozo ; Sugawara, Akira ; Saito, Yoshihiko ; Mukoyama, Masashi ; Arai, Hiroshi ; Imura, Hiroo. / Brain renin-angiotensin : Central control of secretion of atrial natriuretic factor from the heart. In: Hypertension. 1988 ; Vol. 11, No. 2. pp. I-57-I-61.
@article{072fdf4858b04871a6649016cc9221e1,
title = "Brain renin-angiotensin: Central control of secretion of atrial natriuretic factor from the heart",
abstract = "To elucidate the modulatory role of the brain renln-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 fig significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 ± 57 pg/ml; angiotensin II 100 ng, 1110 ± 320 pg/ml, p < 0.01; angiotensin II 1μg, 1055 ± 60 pg/ml, p < 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin H-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V1-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renln-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central α-adrenergic neural pathway.",
keywords = "Blood pressure, Body fluid homeostasis, Central nervous system, V<inf>1</inf> receptor, Vasopressin, Volume expansion, α-adrenergic system",
author = "Hiroshi Itoh and Kazuwa Nakao and Takayuki Yamada and Narito Morii and Shozo Shiono and Akira Sugawara and Yoshihiko Saito and Masashi Mukoyama and Hiroshi Arai and Hiroo Imura",
year = "1988",
language = "English",
volume = "11",
pages = "I--57--I--61",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Brain renin-angiotensin

T2 - Central control of secretion of atrial natriuretic factor from the heart

AU - Itoh, Hiroshi

AU - Nakao, Kazuwa

AU - Yamada, Takayuki

AU - Morii, Narito

AU - Shiono, Shozo

AU - Sugawara, Akira

AU - Saito, Yoshihiko

AU - Mukoyama, Masashi

AU - Arai, Hiroshi

AU - Imura, Hiroo

PY - 1988

Y1 - 1988

N2 - To elucidate the modulatory role of the brain renln-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 fig significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 ± 57 pg/ml; angiotensin II 100 ng, 1110 ± 320 pg/ml, p < 0.01; angiotensin II 1μg, 1055 ± 60 pg/ml, p < 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin H-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V1-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renln-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central α-adrenergic neural pathway.

AB - To elucidate the modulatory role of the brain renln-angiotensin system in the regulation of the secretion of atrial natriuretic factor (ANF) from the heart, the effects of intracerebroventricular administration of angiotensin II on the plasma ANF level were examined in conscious unrestrained rats. Administration of angiotensin II in doses of 100 ng and 1 fig significantly enhanced ANF secretion induced by volume loading with infusion of 3 ml of saline (peak values of the plasma ANF level: control, 220 ± 57 pg/ml; angiotensin II 100 ng, 1110 ± 320 pg/ml, p < 0.01; angiotensin II 1μg, 1055 ± 60 pg/ml, p < 0.01). Injection of angiotensin II alone had no significant effect on the basal plasma ANF level. Central angiotensin H-induced ANF secretion was significantly attenuated by pretreatment with intravenous administration of the V1-receptor antagonist of vasopressin or intracerebroventricular administration of phentolamine. These results indicate that the brain renln-angiotensin system modulates ANF secretion in response to volume loading through the stimulation of vasopressin secretion or the activation of the central α-adrenergic neural pathway.

KW - Blood pressure

KW - Body fluid homeostasis

KW - Central nervous system

KW - V<inf>1</inf> receptor

KW - Vasopressin

KW - Volume expansion

KW - α-adrenergic system

UR - http://www.scopus.com/inward/record.url?scp=0023900261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023900261&partnerID=8YFLogxK

M3 - Article

C2 - 2964405

AN - SCOPUS:0023900261

VL - 11

SP - I-57-I-61

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2

ER -