Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring

T. Fujii, S. Yura, K. Tatsumi, E. Kondoh, H. Mogami, K. Fujita, K. Kakui, S. Aoe, H. Itoh, N. Sagawa, S. Fujii, I. Konishi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Maternal food restriction is known to cause developmental hypertension in offspring. We have previously shown that maternal high-protein diet can reverse fetal programming of hypertension and that branched-chain amino acid (BCAA) concentrations in maternal and fetal plasma were increased by maternal high-protein intake. Then, we hypothesized that isocaloric supplementation with BCAA to a maternal food restriction can reverse the adverse outcome. Pregnant rats were divided into four groups at 7.5 days postcoitum: normally nourished (NN) and 70% undernourished (UN) groups with and without BCAA supplementation (NN-standard diet (SD), NN-BCAA, UN-SD and UN-BCAA groups). Compared with pups in the NN groups, those in the UN-SD group had significantly increased systolic blood pressure (SBP) at 8 and 16 weeks of age (P < 0.05). However, the elevation of SBP was not observed in offspring in the UN-BCAA group. Offspring glomeruli number of the UN groups was significantly lower (P < 0.05) than that of the NN groups, independent of BCAA supplementation. Angiotensin II receptor type 2 (ATR2) mRNA and protein expression in the kidney was significantly augmented in the UN-BCAA group at 30 weeks of age. In conclusion, BCAA supplementation during maternal food restriction prevents developmental hypertension together with increased ATR2 expression in adult offspring kidney.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalJournal of Developmental Origins of Health and Disease
Volume2
Issue number3
DOIs
Publication statusPublished - 2011 Jun
Externally publishedYes

Keywords

  • branched chain amino acids
  • intrauterine undernutrition
  • maternal food restriction
  • sangiotensin II receptor
  • systolic blood pressure

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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