Breast Cancer in Cowden's Disease

A Case Report with Review of the Literature

Yasuhiro Tsubosa, Takashi Fukutomi, Hitoshi Tsuda, Yae Kanai, Sadako Akashi-Tanaka, Takeshi Nanasawa, Gen Linuma, Kyousuke Ushio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report a case of invasive breast cancer in a 62-year-old female patient with Cowden's disease. A left modified radical mastectomy was performed and histopathology of the tumor showed invasive ductal carcinoma, histological grade 3, without lymph node metastasis. The patient had a past history of endometrial cancer at 55 but did not have a family history of malignant disease. Goiter was palpable but aspiration cytology revealed no malignancy. There were several papillomas on the oral mucosa and multiple papillomatous lesions on the right femur. Barium X-ray and endoscopic examination revealed multiple, small, hyperplastic polypoid lesions on the esophagus, stomach and rectum. Histopathology of the biopsy specimens from the esophagus and stomach showed acanthotic squamous epithelium and foveolar hyperplastic polyps. The patient was followed up closely to monitor the thyroid lesions and polyposis of the digestive tract. A total of 12 breast cancer patients who also had Cowden's disease have been reported in Japan and these cases are reviewed in this report.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume28
Issue number1
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Multiple Hamartoma Syndrome
Breast Neoplasms
Esophagus
Stomach
Modified Radical Mastectomy
Ductal Carcinoma
Goiter
Mouth Mucosa
Papilloma
Barium
Endometrial Neoplasms
Polyps
Rectum
Femur
Cell Biology
Gastrointestinal Tract
Neoplasms
Japan
Thyroid Gland
Epithelium

Keywords

  • Breast cancer
  • Cowden's disease
  • Endometrial cancer
  • Goiter

ASJC Scopus subject areas

  • Oncology

Cite this

Tsubosa, Y., Fukutomi, T., Tsuda, H., Kanai, Y., Akashi-Tanaka, S., Nanasawa, T., ... Ushio, K. (1998). Breast Cancer in Cowden's Disease: A Case Report with Review of the Literature. Japanese Journal of Clinical Oncology, 28(1), 42-46.

Breast Cancer in Cowden's Disease : A Case Report with Review of the Literature. / Tsubosa, Yasuhiro; Fukutomi, Takashi; Tsuda, Hitoshi; Kanai, Yae; Akashi-Tanaka, Sadako; Nanasawa, Takeshi; Linuma, Gen; Ushio, Kyousuke.

In: Japanese Journal of Clinical Oncology, Vol. 28, No. 1, 1998, p. 42-46.

Research output: Contribution to journalArticle

Tsubosa, Y, Fukutomi, T, Tsuda, H, Kanai, Y, Akashi-Tanaka, S, Nanasawa, T, Linuma, G & Ushio, K 1998, 'Breast Cancer in Cowden's Disease: A Case Report with Review of the Literature', Japanese Journal of Clinical Oncology, vol. 28, no. 1, pp. 42-46.
Tsubosa Y, Fukutomi T, Tsuda H, Kanai Y, Akashi-Tanaka S, Nanasawa T et al. Breast Cancer in Cowden's Disease: A Case Report with Review of the Literature. Japanese Journal of Clinical Oncology. 1998;28(1):42-46.
Tsubosa, Yasuhiro ; Fukutomi, Takashi ; Tsuda, Hitoshi ; Kanai, Yae ; Akashi-Tanaka, Sadako ; Nanasawa, Takeshi ; Linuma, Gen ; Ushio, Kyousuke. / Breast Cancer in Cowden's Disease : A Case Report with Review of the Literature. In: Japanese Journal of Clinical Oncology. 1998 ; Vol. 28, No. 1. pp. 42-46.
@article{3647f0f6ebb0445eb71632c653aa052a,
title = "Breast Cancer in Cowden's Disease: A Case Report with Review of the Literature",
abstract = "We report a case of invasive breast cancer in a 62-year-old female patient with Cowden's disease. A left modified radical mastectomy was performed and histopathology of the tumor showed invasive ductal carcinoma, histological grade 3, without lymph node metastasis. The patient had a past history of endometrial cancer at 55 but did not have a family history of malignant disease. Goiter was palpable but aspiration cytology revealed no malignancy. There were several papillomas on the oral mucosa and multiple papillomatous lesions on the right femur. Barium X-ray and endoscopic examination revealed multiple, small, hyperplastic polypoid lesions on the esophagus, stomach and rectum. Histopathology of the biopsy specimens from the esophagus and stomach showed acanthotic squamous epithelium and foveolar hyperplastic polyps. The patient was followed up closely to monitor the thyroid lesions and polyposis of the digestive tract. A total of 12 breast cancer patients who also had Cowden's disease have been reported in Japan and these cases are reviewed in this report.",
keywords = "Breast cancer, Cowden's disease, Endometrial cancer, Goiter",
author = "Yasuhiro Tsubosa and Takashi Fukutomi and Hitoshi Tsuda and Yae Kanai and Sadako Akashi-Tanaka and Takeshi Nanasawa and Gen Linuma and Kyousuke Ushio",
year = "1998",
language = "English",
volume = "28",
pages = "42--46",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Breast Cancer in Cowden's Disease

T2 - A Case Report with Review of the Literature

AU - Tsubosa, Yasuhiro

AU - Fukutomi, Takashi

AU - Tsuda, Hitoshi

AU - Kanai, Yae

AU - Akashi-Tanaka, Sadako

AU - Nanasawa, Takeshi

AU - Linuma, Gen

AU - Ushio, Kyousuke

PY - 1998

Y1 - 1998

N2 - We report a case of invasive breast cancer in a 62-year-old female patient with Cowden's disease. A left modified radical mastectomy was performed and histopathology of the tumor showed invasive ductal carcinoma, histological grade 3, without lymph node metastasis. The patient had a past history of endometrial cancer at 55 but did not have a family history of malignant disease. Goiter was palpable but aspiration cytology revealed no malignancy. There were several papillomas on the oral mucosa and multiple papillomatous lesions on the right femur. Barium X-ray and endoscopic examination revealed multiple, small, hyperplastic polypoid lesions on the esophagus, stomach and rectum. Histopathology of the biopsy specimens from the esophagus and stomach showed acanthotic squamous epithelium and foveolar hyperplastic polyps. The patient was followed up closely to monitor the thyroid lesions and polyposis of the digestive tract. A total of 12 breast cancer patients who also had Cowden's disease have been reported in Japan and these cases are reviewed in this report.

AB - We report a case of invasive breast cancer in a 62-year-old female patient with Cowden's disease. A left modified radical mastectomy was performed and histopathology of the tumor showed invasive ductal carcinoma, histological grade 3, without lymph node metastasis. The patient had a past history of endometrial cancer at 55 but did not have a family history of malignant disease. Goiter was palpable but aspiration cytology revealed no malignancy. There were several papillomas on the oral mucosa and multiple papillomatous lesions on the right femur. Barium X-ray and endoscopic examination revealed multiple, small, hyperplastic polypoid lesions on the esophagus, stomach and rectum. Histopathology of the biopsy specimens from the esophagus and stomach showed acanthotic squamous epithelium and foveolar hyperplastic polyps. The patient was followed up closely to monitor the thyroid lesions and polyposis of the digestive tract. A total of 12 breast cancer patients who also had Cowden's disease have been reported in Japan and these cases are reviewed in this report.

KW - Breast cancer

KW - Cowden's disease

KW - Endometrial cancer

KW - Goiter

UR - http://www.scopus.com/inward/record.url?scp=0031611203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031611203&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 42

EP - 46

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 1

ER -