Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

J. Usuda, T. Ohira, Y. Suga, T. Oikawa, S. Ichinose, T. Inoue, K. Ohtani, S. Maehara, K. Imai, M. Kubota, Y. Tsunoda, H. Tsutsui, K. Furukawa, T. Okunaka, Yoshikazu Sugimoto, H. Kato

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalLung Cancer
Volume58
Issue number2
DOIs
Publication statusPublished - 2007 Nov

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Non-Small Cell Lung Carcinoma
Breast Neoplasms
Epidermal Growth Factor Receptor
Codon
Mutation
erbB-1 Genes
Proteins
Threonine
Methionine
Autopsy
Exons
Lung Neoplasms
Smoking
gefitinib

Keywords

  • Acquired resistance
  • BCRP
  • EGFR
  • Gefitinib

ASJC Scopus subject areas

  • Oncology

Cite this

Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer. / Usuda, J.; Ohira, T.; Suga, Y.; Oikawa, T.; Ichinose, S.; Inoue, T.; Ohtani, K.; Maehara, S.; Imai, K.; Kubota, M.; Tsunoda, Y.; Tsutsui, H.; Furukawa, K.; Okunaka, T.; Sugimoto, Yoshikazu; Kato, H.

In: Lung Cancer, Vol. 58, No. 2, 11.2007, p. 296-299.

Research output: Contribution to journalArticle

Usuda, J, Ohira, T, Suga, Y, Oikawa, T, Ichinose, S, Inoue, T, Ohtani, K, Maehara, S, Imai, K, Kubota, M, Tsunoda, Y, Tsutsui, H, Furukawa, K, Okunaka, T, Sugimoto, Y & Kato, H 2007, 'Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer', Lung Cancer, vol. 58, no. 2, pp. 296-299. https://doi.org/10.1016/j.lungcan.2007.05.019
Usuda, J. ; Ohira, T. ; Suga, Y. ; Oikawa, T. ; Ichinose, S. ; Inoue, T. ; Ohtani, K. ; Maehara, S. ; Imai, K. ; Kubota, M. ; Tsunoda, Y. ; Tsutsui, H. ; Furukawa, K. ; Okunaka, T. ; Sugimoto, Yoshikazu ; Kato, H. / Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer. In: Lung Cancer. 2007 ; Vol. 58, No. 2. pp. 296-299.
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