Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

J. Usuda; T. Ohira; Y. Suga; T. Oikawa; S. Ichinose; T. Inoue; K. Ohtani; S. Maehara; K. Imai; M. Kubota; Y. Tsunoda; H. Tsutsui; K. Furukawa; T. Okunaka; Y. Sugimoto; H. Kato

doi:10.1016/j.lungcan.2007.05.019

Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

J. Usuda, T. Ohira, Y. Suga, T. Oikawa, S. Ichinose, T. Inoue, K. Ohtani, S. Maehara, K. Imai, M. Kubota, Y. Tsunoda, H. Tsutsui, K. Furukawa, T. Okunaka, Y. Sugimoto, H. Kato

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.

Original language	English
Pages (from-to)	296-299
Number of pages	4
Journal	Lung Cancer
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/j.lungcan.2007.05.019
Publication status	Published - 2007 Nov

Keywords

Acquired resistance
BCRP
EGFR
Gefitinib

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2007.05.019

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Usuda, J., Ohira, T., Suga, Y., Oikawa, T., Ichinose, S., Inoue, T., Ohtani, K., Maehara, S., Imai, K., Kubota, M., Tsunoda, Y., Tsutsui, H., Furukawa, K., Okunaka, T., Sugimoto, Y., & Kato, H. (2007). Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer. Lung Cancer, 58(2), 296-299. https://doi.org/10.1016/j.lungcan.2007.05.019

Usuda, J, Ohira, T, Suga, Y, Oikawa, T, Ichinose, S, Inoue, T, Ohtani, K, Maehara, S, Imai, K, Kubota, M, Tsunoda, Y, Tsutsui, H, Furukawa, K, Okunaka, T, Sugimoto, Y & Kato, H 2007, 'Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer', Lung Cancer, vol. 58, no. 2, pp. 296-299. https://doi.org/10.1016/j.lungcan.2007.05.019

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abstract = "Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a {"}never smoking{"} woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.",

keywords = "Acquired resistance, BCRP, EGFR, Gefitinib",

author = "J. Usuda and T. Ohira and Y. Suga and T. Oikawa and S. Ichinose and T. Inoue and K. Ohtani and S. Maehara and K. Imai and M. Kubota and Y. Tsunoda and H. Tsutsui and K. Furukawa and T. Okunaka and Y. Sugimoto and H. Kato",

note = "Funding Information: This work was supported in part by Grant-in-Aid for Young Scientist (B) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). KAKENHI 18791002 (J.U.).",

year = "2007",

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doi = "10.1016/j.lungcan.2007.05.019",

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T1 - Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

AU - Usuda, J.

AU - Ohira, T.

AU - Suga, Y.

AU - Oikawa, T.

AU - Ichinose, S.

AU - Inoue, T.

AU - Ohtani, K.

AU - Maehara, S.

AU - Imai, K.

AU - Kubota, M.

AU - Tsunoda, Y.

AU - Tsutsui, H.

AU - Furukawa, K.

AU - Okunaka, T.

AU - Sugimoto, Y.

AU - Kato, H.

N1 - Funding Information: This work was supported in part by Grant-in-Aid for Young Scientist (B) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). KAKENHI 18791002 (J.U.).

PY - 2007/11

Y1 - 2007/11

N2 - Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.

AB - Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.

KW - Acquired resistance

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KW - EGFR

KW - Gefitinib

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Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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