Breast cancer stem cells

Kazuharu Kai, Yoshimi Arima, Toshio Kamiya, Hideyuki Saya

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44- positive (CD24-/ CD44+) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalBreast Cancer
Volume17
Issue number2
DOIs
Publication statusPublished - 2010 Apr

Fingerprint

Neoplastic Stem Cells
Breast Neoplasms
Stem Cells
Neoplasms
Intrinsic Factor
Investigational Therapies
Human Mammary Glands
Leukemia
Oxidative Stress
Membranes
Research

Keywords

  • Epithelial to mesenchymal transition (EMT)
  • Niche
  • Self-renewal
  • Somatic (tissue-specific) stem cell

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Breast cancer stem cells. / Kai, Kazuharu; Arima, Yoshimi; Kamiya, Toshio; Saya, Hideyuki.

In: Breast Cancer, Vol. 17, No. 2, 04.2010, p. 80-85.

Research output: Contribution to journalArticle

Kai, Kazuharu ; Arima, Yoshimi ; Kamiya, Toshio ; Saya, Hideyuki. / Breast cancer stem cells. In: Breast Cancer. 2010 ; Vol. 17, No. 2. pp. 80-85.
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