Reductive homologation of thiophenecarboxyaldehyde mediated by brewers' yeast and subsequent recrystallization provided (1S,2S)-1-(2-thienyl)-1,2-propanediol in 29% yield. A Pseudomonas lipase-catalyzed acetylation preferentially occurred on the hydroxyl group at C-1 position of the diol.
|Number of pages||8|
|Publication status||Published - 1997 Dec 1|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry