Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh, Luis Augusto Eijy Nagai, Kosuke Hashimoto, Sung Joon Park, Aoi Shibuya, Ana Maria Suzuki, Yujiro Tanaka, Kenta Nakai, Piero Carninci, Hiroyuki Sasaki, Haruhiko Siomi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

Original languageEnglish
Pages (from-to)21-34.e5
JournalDevelopmental Cell
Volume51
Issue number1
DOIs
Publication statusPublished - 2019 Oct 7

Fingerprint

DNA Methylation
Genes
Genome
Methyltransferases
Chromatin
Cells
DNA
Embryonic Germ Cells

Keywords

  • ATAC-seq
  • de novo DNA methylation
  • gene cluster
  • gene desert
  • gonocyte
  • transposon

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., ... Siomi, H. (2019). Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. Developmental Cell, 51(1), 21-34.e5. https://doi.org/10.1016/j.devcel.2019.07.023

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. / Yamanaka, Soichiro; Nishihara, Hidenori; Toh, Hidehiro; Eijy Nagai, Luis Augusto; Hashimoto, Kosuke; Park, Sung Joon; Shibuya, Aoi; Suzuki, Ana Maria; Tanaka, Yujiro; Nakai, Kenta; Carninci, Piero; Sasaki, Hiroyuki; Siomi, Haruhiko.

In: Developmental Cell, Vol. 51, No. 1, 07.10.2019, p. 21-34.e5.

Research output: Contribution to journalArticle

Yamanaka, S, Nishihara, H, Toh, H, Eijy Nagai, LA, Hashimoto, K, Park, SJ, Shibuya, A, Suzuki, AM, Tanaka, Y, Nakai, K, Carninci, P, Sasaki, H & Siomi, H 2019, 'Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation', Developmental Cell, vol. 51, no. 1, pp. 21-34.e5. https://doi.org/10.1016/j.devcel.2019.07.023
Yamanaka S, Nishihara H, Toh H, Eijy Nagai LA, Hashimoto K, Park SJ et al. Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. Developmental Cell. 2019 Oct 7;51(1):21-34.e5. https://doi.org/10.1016/j.devcel.2019.07.023
Yamanaka, Soichiro ; Nishihara, Hidenori ; Toh, Hidehiro ; Eijy Nagai, Luis Augusto ; Hashimoto, Kosuke ; Park, Sung Joon ; Shibuya, Aoi ; Suzuki, Ana Maria ; Tanaka, Yujiro ; Nakai, Kenta ; Carninci, Piero ; Sasaki, Hiroyuki ; Siomi, Haruhiko. / Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. In: Developmental Cell. 2019 ; Vol. 51, No. 1. pp. 21-34.e5.
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