Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh, Luis Augusto Eijy Nagai, Kosuke Hashimoto, Sung Joon Park, Aoi Shibuya, Ana Maria Suzuki, Yujiro Tanaka, Kenta Nakai, Piero Carninci, Hiroyuki Sasaki, Haruhiko Siomi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

Original languageEnglish
Pages (from-to)21-34.e5
JournalDevelopmental Cell
Volume51
Issue number1
DOIs
Publication statusPublished - 2019 Oct 7

Keywords

  • ATAC-seq
  • de novo DNA methylation
  • gene cluster
  • gene desert
  • gonocyte
  • transposon

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H., & Siomi, H. (2019). Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. Developmental Cell, 51(1), 21-34.e5. https://doi.org/10.1016/j.devcel.2019.07.023