Bronchoscopic assessment of bronchial anastomosis by visualizing local circulation status-index of hemoglobin (IHb) imaging

Takayoshi Yamamoto, Shigetoshi Yoshida, Takahiro Nakajima, Taiki Fujiwara, Hidemi Suzuki, Takekazu Iwata, Yasunori Sato, Ichiro Yoshino

Research output: Contribution to journalArticle

Abstract

Background: Healing of airway anastomosis is largely affected by local circulation. Index of hemoglobin (IHb) imaging is a color enhancement technique that clarifies local circulation in the gastrointestinal endoscopic field. In this study, we investigated the relationship between bronchoscopic assessment of bronchial anastomosis using IHb mode and occurrence of anastomosis-related complications. Methods: IHb was calculated by logarithmic transformation for each pixel of the electronic endoscopic images and expressed by colors of red, green, and blue. The distribution of each color area was automatically calculated by the summation of pixels. A preliminary experiment spraying vasodilator on swine was performed to confirm the relationship between bronchial mucosal circulation and the IHb image. Forty consecutive patients who underwent bronchoplasty were divided into retrospective training and prospective validation cohorts, and anastomosis-related complications and IHb images were analyzed. Results: The IHb images immediately and accurately reflected the mucosal changes in the animal experiment. Among 25 cases in the retrospective training cohort, 6 cases experienced complications, with significantly lower red and higher blue values in IHb observed (P=0.03 and P=0.01, respectively). A receiver operating characteristic (ROC) curve for IHb red and blue distributions revealed the thresholds to differentiate cases with complications as 89.2 and 109.0, respectively. An analysis of the prospective validation cohort revealed that IHb blue on POD 7 was a potentially reliable predictor of complications, with 60.0% sensitivity and 90.0% specificity. Conclusions: IHb mode of bronchoscopy may be useful for assessing the local circulatory condition of bronchoplasty, which can predict anastomosis-related morbidity.

Original languageEnglish
Pages (from-to)2196-2205
Number of pages10
JournalJournal of Thoracic Disease
Volume10
Issue number4
DOIs
Publication statusPublished - 2018 Apr 1
Externally publishedYes

Fingerprint

Hemoglobins
Color
Bronchoscopy
Vasodilator Agents
ROC Curve
Swine
Morbidity
Sensitivity and Specificity

Keywords

  • Bronchial anastomosis
  • Bronchoplasty
  • Lung cancer
  • Surgery

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bronchoscopic assessment of bronchial anastomosis by visualizing local circulation status-index of hemoglobin (IHb) imaging. / Yamamoto, Takayoshi; Yoshida, Shigetoshi; Nakajima, Takahiro; Fujiwara, Taiki; Suzuki, Hidemi; Iwata, Takekazu; Sato, Yasunori; Yoshino, Ichiro.

In: Journal of Thoracic Disease, Vol. 10, No. 4, 01.04.2018, p. 2196-2205.

Research output: Contribution to journalArticle

Yamamoto, Takayoshi ; Yoshida, Shigetoshi ; Nakajima, Takahiro ; Fujiwara, Taiki ; Suzuki, Hidemi ; Iwata, Takekazu ; Sato, Yasunori ; Yoshino, Ichiro. / Bronchoscopic assessment of bronchial anastomosis by visualizing local circulation status-index of hemoglobin (IHb) imaging. In: Journal of Thoracic Disease. 2018 ; Vol. 10, No. 4. pp. 2196-2205.
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abstract = "Background: Healing of airway anastomosis is largely affected by local circulation. Index of hemoglobin (IHb) imaging is a color enhancement technique that clarifies local circulation in the gastrointestinal endoscopic field. In this study, we investigated the relationship between bronchoscopic assessment of bronchial anastomosis using IHb mode and occurrence of anastomosis-related complications. Methods: IHb was calculated by logarithmic transformation for each pixel of the electronic endoscopic images and expressed by colors of red, green, and blue. The distribution of each color area was automatically calculated by the summation of pixels. A preliminary experiment spraying vasodilator on swine was performed to confirm the relationship between bronchial mucosal circulation and the IHb image. Forty consecutive patients who underwent bronchoplasty were divided into retrospective training and prospective validation cohorts, and anastomosis-related complications and IHb images were analyzed. Results: The IHb images immediately and accurately reflected the mucosal changes in the animal experiment. Among 25 cases in the retrospective training cohort, 6 cases experienced complications, with significantly lower red and higher blue values in IHb observed (P=0.03 and P=0.01, respectively). A receiver operating characteristic (ROC) curve for IHb red and blue distributions revealed the thresholds to differentiate cases with complications as 89.2 and 109.0, respectively. An analysis of the prospective validation cohort revealed that IHb blue on POD 7 was a potentially reliable predictor of complications, with 60.0{\%} sensitivity and 90.0{\%} specificity. Conclusions: IHb mode of bronchoscopy may be useful for assessing the local circulatory condition of bronchoplasty, which can predict anastomosis-related morbidity.",
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AU - Fujiwara, Taiki

AU - Suzuki, Hidemi

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AU - Sato, Yasunori

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