Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

HPB Organoid Consortium

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.

Original languageEnglish
Pages (from-to)816-832
Number of pages17
JournalCell stem cell
Volume28
Issue number5
DOIs
Publication statusPublished - 2021 May 6

Keywords

  • Delphi method
  • HPB
  • bile duct
  • epithelial organoid
  • gallbladder
  • liver
  • multi-organ organoid
  • multi-tissue organoid
  • pancreas
  • tumor organoid

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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