c-erbB-2 gene product associates with catenins in human cancer cells

Atsushi Ochiai, Shingo Akimoto, Yae Kanai, Tatsuhiro Shibata, Tsukasa Oyama, Setsuo Hirohashi

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Phosphorylation of β-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proved to be mediated through β-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume205
Issue number1
DOIs
Publication statusPublished - 1994 Nov 30
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'c-erbB-2 gene product associates with catenins in human cancer cells'. Together they form a unique fingerprint.

  • Cite this