c-erbB-2 gene product associates with catenins in human cancer cells

A. Ochiai, S. Akimoto, Yae Kanai, T. Shibata, T. Oyama, S. Hirohashi

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Phosphorylation of β-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proved to be mediated through β-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume205
Issue number1
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

erbB-2 Genes
Catenins
Cadherins
Genes
Cells
Cell adhesion
Neoplasms
Cell Adhesion
gamma Catenin
Phosphorylation
Proteins
Carrier Proteins
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

c-erbB-2 gene product associates with catenins in human cancer cells. / Ochiai, A.; Akimoto, S.; Kanai, Yae; Shibata, T.; Oyama, T.; Hirohashi, S.

In: Biochemical and Biophysical Research Communications, Vol. 205, No. 1, 1994, p. 73-78.

Research output: Contribution to journalArticle

Ochiai, A. ; Akimoto, S. ; Kanai, Yae ; Shibata, T. ; Oyama, T. ; Hirohashi, S. / c-erbB-2 gene product associates with catenins in human cancer cells. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 205, No. 1. pp. 73-78.
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