TY - JOUR
T1 - C-fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection
AU - Maruyama, Kenta
AU - Sano, Gen Ichiro
AU - Ray, Neelanjan
AU - Takada, Yasunari
AU - Matsuo, Koichi
PY - 2007/3
Y1 - 2007/3
N2 - c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-κB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.
AB - c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-κB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.
UR - http://www.scopus.com/inward/record.url?scp=33847709132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847709132&partnerID=8YFLogxK
U2 - 10.1128/IAI.01316-06
DO - 10.1128/IAI.01316-06
M3 - Article
C2 - 17178788
AN - SCOPUS:33847709132
SN - 0019-9567
VL - 75
SP - 1520
EP - 1523
JO - Infection and Immunity
JF - Infection and Immunity
IS - 3
ER -
