C-fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection

Kenta Maruyama, Gen Ichiro Sano, Neelanjan Ray, Yasunari Takada, Koichi Matsuo

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-κB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.

Original languageEnglish
Pages (from-to)1520-1523
Number of pages4
JournalInfection and Immunity
Volume75
Issue number3
DOIs
Publication statusPublished - 2007 Mar

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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