C-fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection

Kenta Maruyama, Gen Ichiro Sano, Neelanjan Ray, Yasunari Takada, Koichi Matsuo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-κB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.

Original languageEnglish
Pages (from-to)1520-1523
Number of pages4
JournalInfection and Immunity
Volume75
Issue number3
DOIs
Publication statusPublished - 2007 Mar

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Salmonella enterica
Salmonella Infections
Transcription Factor AP-1
Infection
Cell Death
Macrophages
Phosphorylation
Cytokines
Serogroup

ASJC Scopus subject areas

  • Immunology

Cite this

C-fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection. / Maruyama, Kenta; Sano, Gen Ichiro; Ray, Neelanjan; Takada, Yasunari; Matsuo, Koichi.

In: Infection and Immunity, Vol. 75, No. 3, 03.2007, p. 1520-1523.

Research output: Contribution to journalArticle

Maruyama, Kenta ; Sano, Gen Ichiro ; Ray, Neelanjan ; Takada, Yasunari ; Matsuo, Koichi. / C-fos-deficient mice are susceptible to Salmonella enterica serovar typhimurium infection. In: Infection and Immunity. 2007 ; Vol. 75, No. 3. pp. 1520-1523.
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