TY - JOUR
T1 - Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity
AU - Sato, Tomoyuki
AU - Arai, Midori A.
AU - Yixizhuoma,
AU - Hara, Yasumasa
AU - Koyano, Takashi
AU - Kowithayakorn, Thaworn
AU - Ishibashi, Masami
N1 - Funding Information:
This study was supported by KAKENHI Grant Numbers 18H02582 and 17H03992 from the Japan Society for the Promotion of Science (JSPS).
Funding Information:
We would like to thank Professor Jeremy Nathans (John Hopkins University School of Medicine) for the STF/293 cells and Professor Ronald T. Moon (University of Washington) for the Super FOPFlash plasmid.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.
AB - Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.
KW - Cadinane
KW - Santalum album
KW - Sesquiterpene
KW - Wnt
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U2 - 10.1007/s11418-019-01380-x
DO - 10.1007/s11418-019-01380-x
M3 - Article
C2 - 31863259
AN - SCOPUS:85077085636
VL - 74
SP - 476
EP - 481
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1861-0293
IS - 2
ER -