Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity

Tomoyuki Sato; Midori A. Arai; Yixizhuoma; Yasumasa Hara; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi

doi:10.1007/s11418-019-01380-x

Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity

Tomoyuki Sato, Midori A. Arai, Yixizhuoma, Yasumasa Hara, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

Department of Biosciences and Informatics

Research output: Contribution to journal › Article

Abstract

Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC₅₀ of 1.2 μM.

Original language	English
Pages (from-to)	476-481
Number of pages	6
Journal	Journal of Natural Medicines
Volume	74
Issue number	2
DOIs	https://doi.org/10.1007/s11418-019-01380-x
Publication status	Published - 2020 Mar 1

Keywords

Cadinane
Santalum album
Sesquiterpene
Wnt

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1007/s11418-019-01380-x

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Sato, T., Arai, M. A., Yixizhuoma, Hara, Y., Koyano, T., Kowithayakorn, T., & Ishibashi, M. (2020). Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity. Journal of Natural Medicines, 74(2), 476-481. https://doi.org/10.1007/s11418-019-01380-x

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AU - Koyano, Takashi

AU - Kowithayakorn, Thaworn

AU - Ishibashi, Masami

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