Calbindin-D28k in cerebrovascular extrinsic innervation system of the rat

Toshihiko Shimizu, Norihiro Suzuki, Masaki Takao, Atsuo Koto, Yasuo Fukuuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Calbindin-D28k, one of the calcium-binding proteins, belongs to the EF hand family and is commonly found in neurons. It serves as a representative neuronal marker for neuroanatomical investigations. The authors' knowledge of its precise function, however, is yet very limited. In this study, we examined the existence of nerve fibers with calbindin-D28k immunoreactivity in the cerebral blood vessels and ganglia that innervate the cerebral blood vessels in the rat. Numerous nerve fibers with calbindin-D28k immunoreactivity were observed on the walls of the major extracerebral arteries forming the circle of Willis and its branches. Calbindin-D28k immunoreactivity was seen in many neurons of the trigeminal, dorsal root and jugular ganglia. A small number of neurons showed calbindin-D28k immunoreactivity in the otic and superior cervical ganglia. Calbindin-D28k immunoreactivity was not detected in the sphenopalatine or internal carotid ganglia. Pericellular basket-like formations of nerve terminals with calbindin-D28k immunoreactivity were observed in the sphenopalatine, otic, internal carotid and superior cervical ganglia. The present study demonstrated calbindin-D28k immunoreactivity in the cerebrovascular nerve fibers as well as in their origins - the cranial ganglia. These findings are significant in understanding the calcium-mediated mechanism of the neural control of the cerebral blood vessels. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)130-139
Number of pages10
JournalAutonomic Neuroscience: Basic and Clinical
Volume84
Issue number3
DOIs
Publication statusPublished - 2000 Nov 1

Fingerprint

Calbindin 1
Nerve Fibers
Ganglia
Blood Vessels
Superior Cervical Ganglion
Neurons
Ear
Circle of Willis
EF Hand Motifs
Calcium-Binding Proteins
Spinal Ganglia
Neck
Arteries
Calcium

Keywords

  • Calcium-binding protein
  • Cerebral blood vessel
  • Parasympathetic ganglion
  • Sensory ganglion
  • Sympathetic ganglion

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Calbindin-D28k in cerebrovascular extrinsic innervation system of the rat. / Shimizu, Toshihiko; Suzuki, Norihiro; Takao, Masaki; Koto, Atsuo; Fukuuchi, Yasuo.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 84, No. 3, 01.11.2000, p. 130-139.

Research output: Contribution to journalArticle

Shimizu, Toshihiko ; Suzuki, Norihiro ; Takao, Masaki ; Koto, Atsuo ; Fukuuchi, Yasuo. / Calbindin-D28k in cerebrovascular extrinsic innervation system of the rat. In: Autonomic Neuroscience: Basic and Clinical. 2000 ; Vol. 84, No. 3. pp. 130-139.
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