Calbindin-D28k in cerebrovascular extrinsic innervation system of the rat

Toshihiko Shimizu, Norihiro Suzuki, Masaki Takao, Atsuo Koto, Yasuo Fukuuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Calbindin-D28k, one of the calcium-binding proteins, belongs to the EF hand family and is commonly found in neurons. It serves as a representative neuronal marker for neuroanatomical investigations. The authors' knowledge of its precise function, however, is yet very limited. In this study, we examined the existence of nerve fibers with calbindin-D28k immunoreactivity in the cerebral blood vessels and ganglia that innervate the cerebral blood vessels in the rat. Numerous nerve fibers with calbindin-D28k immunoreactivity were observed on the walls of the major extracerebral arteries forming the circle of Willis and its branches. Calbindin-D28k immunoreactivity was seen in many neurons of the trigeminal, dorsal root and jugular ganglia. A small number of neurons showed calbindin-D28k immunoreactivity in the otic and superior cervical ganglia. Calbindin-D28k immunoreactivity was not detected in the sphenopalatine or internal carotid ganglia. Pericellular basket-like formations of nerve terminals with calbindin-D28k immunoreactivity were observed in the sphenopalatine, otic, internal carotid and superior cervical ganglia. The present study demonstrated calbindin-D28k immunoreactivity in the cerebrovascular nerve fibers as well as in their origins - the cranial ganglia. These findings are significant in understanding the calcium-mediated mechanism of the neural control of the cerebral blood vessels. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)130-139
Number of pages10
JournalAutonomic Neuroscience: Basic and Clinical
Volume84
Issue number3
DOIs
Publication statusPublished - 2000 Nov 1

Keywords

  • Calcium-binding protein
  • Cerebral blood vessel
  • Parasympathetic ganglion
  • Sensory ganglion
  • Sympathetic ganglion

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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