Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method

Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydrothermal processing plays a key role in the synthesis of biomaterials with excellent biocompatibility in the physiological environment. Especially, calcium phosphates are paid to much attention for the regenerative medicine. Two kinds of porous materials of hydroxyapatite with 70% porosity were prepared. One of them is a newly developed calcium-deficient hydroxyapatite composed of rod-shaped particles of about 20 μm in length synthesized hydrothermally (HHA) and the other one is the stoichiometric hydroxyapatite (SHA) prepared by the conventional sintering method. These materials were used for animal implantation tests to compare these biological responses. In the rabbit femur, implanted HHA was slowly resorbed and then most of the implanted HHA was resorbed after 72 weeks. The implanted SHA was unresorbed throughout the experimental period. The volume of newly formed bone and the number of osteoclasts in the implanted region were significantly larger in HHA than in SHA after 24 weeks. Results in the present research suggested that the activity of osteoclasts correlated to the bone forming activity of osteoblasts. The method to synthesize biodegradable pure calcium-deficient HA is expected to provide adequate biodegradability and bone replaceability.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages304-307
Number of pages4
Volume1251
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy - Sanya, China
Duration: 2009 Dec 72009 Dec 10

Other

Other2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy
CountryChina
CitySanya
Period09/12/709/12/10

Fingerprint

bones
calcium
biodegradability
femur
osteoblasts
calcium phosphates
rabbits
biocompatibility
porous materials
medicine
animals
implantation
sintering
rods
porosity
synthesis

Keywords

  • Hydrothermal
  • Hydroxyapatite calcium phosphate

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Ioku, K., Kamitakahara, M., & Ikeda, T. (2010). Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. In AIP Conference Proceedings (Vol. 1251, pp. 304-307) https://doi.org/10.1063/1.3456339

Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. / Ioku, Koji; Kamitakahara, Masanobu; Ikeda, Tohru.

AIP Conference Proceedings. Vol. 1251 2010. p. 304-307.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ioku, K, Kamitakahara, M & Ikeda, T 2010, Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. in AIP Conference Proceedings. vol. 1251, pp. 304-307, 2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy, Sanya, China, 09/12/7. https://doi.org/10.1063/1.3456339
Ioku K, Kamitakahara M, Ikeda T. Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. In AIP Conference Proceedings. Vol. 1251. 2010. p. 304-307 https://doi.org/10.1063/1.3456339
Ioku, Koji ; Kamitakahara, Masanobu ; Ikeda, Tohru. / Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. AIP Conference Proceedings. Vol. 1251 2010. pp. 304-307
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