Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method

Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydrothermal processing plays a key role in the synthesis of biomaterials with excellent biocompatibility in the physiological environment. Especially, calcium phosphates are paid to much attention for the regenerative medicine. Two kinds of porous materials of hydroxyapatite with 70% porosity were prepared. One of them is a newly developed calcium-deficient hydroxyapatite composed of rod-shaped particles of about 20 μm in length synthesized hydrothermally (HHA) and the other one is the stoichiometric hydroxyapatite (SHA) prepared by the conventional sintering method. These materials were used for animal implantation tests to compare these biological responses. In the rabbit femur, implanted HHA was slowly resorbed and then most of the implanted HHA was resorbed after 72 weeks. The implanted SHA was unresorbed throughout the experimental period. The volume of newly formed bone and the number of osteoclasts in the implanted region were significantly larger in HHA than in SHA after 24 weeks. Results in the present research suggested that the activity of osteoclasts correlated to the bone forming activity of osteoblasts. The method to synthesize biodegradable pure calcium-deficient HA is expected to provide adequate biodegradability and bone replaceability.

Original languageEnglish
Title of host publication2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy
Pages304-307
Number of pages4
DOIs
Publication statusPublished - 2010 Dec 1
Externally publishedYes
Event2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy - Sanya, China
Duration: 2009 Dec 72009 Dec 10

Publication series

NameAIP Conference Proceedings
Volume1251
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy
CountryChina
CitySanya
Period09/12/709/12/10

Keywords

  • Hydrothermal
  • Hydroxyapatite calcium phosphate

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Ioku, K., Kamitakahara, M., & Ikeda, T. (2010). Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method. In 2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy (pp. 304-307). (AIP Conference Proceedings; Vol. 1251). https://doi.org/10.1063/1.3456339