Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells

Wanshui Yang, Li Liu, Na Na Keum, Zhi Rong Qian, Jonathan A. Nowak, Tsuyoshi Hamada, Mingyang Song, Yin Cao, Katsuhiko Nosho, Stephanie A. Smith-Warner, Sui Zhang, Yohei Masugi, Kimmie Ng, Keisuke Kosumi, Yanan Ma, Wendy S. Garrett, Molin Wang, Hongmei Nan, Marios Giannakis, Jeffrey A. Meyerhardt & 7 others Andrew T. Chan, Charles S. Fuchs, Reiko Nishihara, Kana Wu, Edward L. Giovannucci, Shuji Ogino, Xuehong Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Calcium intake has been associated with a lower risk 0.36–0.84; Ptrend ¼ 0.002) for CD8þ T-cell–low but not of colorectal cancer. Calcium signaling may enhance for CD8þ T-cell–high tumors (HR ¼ 1.02; 95% CI, T-cell proliferation and differentiation, and contribute 0.67–1.55; Ptrend ¼ 0.47). Similarly, the corresponding to T-cell–mediated antitumor immunity. In this pro-HRs (95% CIs) for calcium for low versus high T-cell–spective cohort study, we investigated the association infiltrated tumors were 0.63 (0.42–0.94; Ptrend ¼ 0.01) between calcium intake and colorectal cancer risk and 0.89 (0.58–1.35; Ptrend ¼ 0.20) for CD3þ; according to tumor immunity status to provide addi-0.58 (0.39–0.87; Ptrend ¼ 0.006) and 1.04 (0.69–tional insights into the role of calcium in colorectal 1.58; Ptrend ¼ 0.54) for CD45ROþ; and 0.56 (0.36–carcinogenesis. The densities of tumor-infiltrating 0.85; Ptrend ¼ 0.006) and 1.10 (0.72–1.67; Ptrend ¼ T-cell subsets [CD3þ, CD8þ, CD45RO (PTPRC)þ, or 0.47) for FOXP3þ, although the differences by sub-FOXP3þ cell] were assessed using IHC and computer-types defined by T-cell density were not statistically assisted image analysis in 736 cancer cases that devel-significant. These potential differential associations oped among 136,249 individuals in two cohorts. HRs generally appeared consistent regardless of sex, source and 95% confidence intervals (CI) were calculated of calcium intake, tumor location, and tumor micro-using Cox proportional hazards regression. Total cal-satellite instability status. Our findings suggest a pos-cium intake was associated with a multivariable HR of sible role of calcium in cancer immunoprevention via 0.55 (comparing 1,200 vs. <600 mg/day; 95% CI, modulation of T-cell function.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalCancer Prevention Research
Volume12
Issue number5
DOIs
Publication statusPublished - 2019 May 1
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Calcium
T-Lymphocytes
Neoplasms
Confidence Intervals
Immunity
Calcium Signaling
T-Lymphocyte Subsets
Cell Differentiation
Cohort Studies
Cell Count
Cell Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yang, W., Liu, L., Keum, N. N., Qian, Z. R., Nowak, J. A., Hamada, T., ... Zhang, X. (2019). Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells. Cancer Prevention Research, 12(5), 283-293. https://doi.org/10.1158/1940-6207.CAPR-18-0279

Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells. / Yang, Wanshui; Liu, Li; Keum, Na Na; Qian, Zhi Rong; Nowak, Jonathan A.; Hamada, Tsuyoshi; Song, Mingyang; Cao, Yin; Nosho, Katsuhiko; Smith-Warner, Stephanie A.; Zhang, Sui; Masugi, Yohei; Ng, Kimmie; Kosumi, Keisuke; Ma, Yanan; Garrett, Wendy S.; Wang, Molin; Nan, Hongmei; Giannakis, Marios; Meyerhardt, Jeffrey A.; Chan, Andrew T.; Fuchs, Charles S.; Nishihara, Reiko; Wu, Kana; Giovannucci, Edward L.; Ogino, Shuji; Zhang, Xuehong.

In: Cancer Prevention Research, Vol. 12, No. 5, 01.05.2019, p. 283-293.

Research output: Contribution to journalArticle

Yang, W, Liu, L, Keum, NN, Qian, ZR, Nowak, JA, Hamada, T, Song, M, Cao, Y, Nosho, K, Smith-Warner, SA, Zhang, S, Masugi, Y, Ng, K, Kosumi, K, Ma, Y, Garrett, WS, Wang, M, Nan, H, Giannakis, M, Meyerhardt, JA, Chan, AT, Fuchs, CS, Nishihara, R, Wu, K, Giovannucci, EL, Ogino, S & Zhang, X 2019, 'Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells', Cancer Prevention Research, vol. 12, no. 5, pp. 283-293. https://doi.org/10.1158/1940-6207.CAPR-18-0279
Yang, Wanshui ; Liu, Li ; Keum, Na Na ; Qian, Zhi Rong ; Nowak, Jonathan A. ; Hamada, Tsuyoshi ; Song, Mingyang ; Cao, Yin ; Nosho, Katsuhiko ; Smith-Warner, Stephanie A. ; Zhang, Sui ; Masugi, Yohei ; Ng, Kimmie ; Kosumi, Keisuke ; Ma, Yanan ; Garrett, Wendy S. ; Wang, Molin ; Nan, Hongmei ; Giannakis, Marios ; Meyerhardt, Jeffrey A. ; Chan, Andrew T. ; Fuchs, Charles S. ; Nishihara, Reiko ; Wu, Kana ; Giovannucci, Edward L. ; Ogino, Shuji ; Zhang, Xuehong. / Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells. In: Cancer Prevention Research. 2019 ; Vol. 12, No. 5. pp. 283-293.
@article{fe70a09dc25e43f09247d466c1f13ddc,
title = "Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells",
abstract = "Calcium intake has been associated with a lower risk 0.36–0.84; Ptrend ¼ 0.002) for CD8{\th} T-cell–low but not of colorectal cancer. Calcium signaling may enhance for CD8{\th} T-cell–high tumors (HR ¼ 1.02; 95{\%} CI, T-cell proliferation and differentiation, and contribute 0.67–1.55; Ptrend ¼ 0.47). Similarly, the corresponding to T-cell–mediated antitumor immunity. In this pro-HRs (95{\%} CIs) for calcium for low versus high T-cell–spective cohort study, we investigated the association infiltrated tumors were 0.63 (0.42–0.94; Ptrend ¼ 0.01) between calcium intake and colorectal cancer risk and 0.89 (0.58–1.35; Ptrend ¼ 0.20) for CD3{\th}; according to tumor immunity status to provide addi-0.58 (0.39–0.87; Ptrend ¼ 0.006) and 1.04 (0.69–tional insights into the role of calcium in colorectal 1.58; Ptrend ¼ 0.54) for CD45RO{\th}; and 0.56 (0.36–carcinogenesis. The densities of tumor-infiltrating 0.85; Ptrend ¼ 0.006) and 1.10 (0.72–1.67; Ptrend ¼ T-cell subsets [CD3{\th}, CD8{\th}, CD45RO (PTPRC){\th}, or 0.47) for FOXP3{\th}, although the differences by sub-FOXP3{\th} cell] were assessed using IHC and computer-types defined by T-cell density were not statistically assisted image analysis in 736 cancer cases that devel-significant. These potential differential associations oped among 136,249 individuals in two cohorts. HRs generally appeared consistent regardless of sex, source and 95{\%} confidence intervals (CI) were calculated of calcium intake, tumor location, and tumor micro-using Cox proportional hazards regression. Total cal-satellite instability status. Our findings suggest a pos-cium intake was associated with a multivariable HR of sible role of calcium in cancer immunoprevention via 0.55 (comparing 1,200 vs. <600 mg/day; 95{\%} CI, modulation of T-cell function.",
author = "Wanshui Yang and Li Liu and Keum, {Na Na} and Qian, {Zhi Rong} and Nowak, {Jonathan A.} and Tsuyoshi Hamada and Mingyang Song and Yin Cao and Katsuhiko Nosho and Smith-Warner, {Stephanie A.} and Sui Zhang and Yohei Masugi and Kimmie Ng and Keisuke Kosumi and Yanan Ma and Garrett, {Wendy S.} and Molin Wang and Hongmei Nan and Marios Giannakis and Meyerhardt, {Jeffrey A.} and Chan, {Andrew T.} and Fuchs, {Charles S.} and Reiko Nishihara and Kana Wu and Giovannucci, {Edward L.} and Shuji Ogino and Xuehong Zhang",
year = "2019",
month = "5",
day = "1",
doi = "10.1158/1940-6207.CAPR-18-0279",
language = "English",
volume = "12",
pages = "283--293",
journal = "Cancer Prevention Research",
issn = "1940-6207",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Calcium intake and risk of colorectal cancer according to tumor-infiltrating T cells

AU - Yang, Wanshui

AU - Liu, Li

AU - Keum, Na Na

AU - Qian, Zhi Rong

AU - Nowak, Jonathan A.

AU - Hamada, Tsuyoshi

AU - Song, Mingyang

AU - Cao, Yin

AU - Nosho, Katsuhiko

AU - Smith-Warner, Stephanie A.

AU - Zhang, Sui

AU - Masugi, Yohei

AU - Ng, Kimmie

AU - Kosumi, Keisuke

AU - Ma, Yanan

AU - Garrett, Wendy S.

AU - Wang, Molin

AU - Nan, Hongmei

AU - Giannakis, Marios

AU - Meyerhardt, Jeffrey A.

AU - Chan, Andrew T.

AU - Fuchs, Charles S.

AU - Nishihara, Reiko

AU - Wu, Kana

AU - Giovannucci, Edward L.

AU - Ogino, Shuji

AU - Zhang, Xuehong

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Calcium intake has been associated with a lower risk 0.36–0.84; Ptrend ¼ 0.002) for CD8þ T-cell–low but not of colorectal cancer. Calcium signaling may enhance for CD8þ T-cell–high tumors (HR ¼ 1.02; 95% CI, T-cell proliferation and differentiation, and contribute 0.67–1.55; Ptrend ¼ 0.47). Similarly, the corresponding to T-cell–mediated antitumor immunity. In this pro-HRs (95% CIs) for calcium for low versus high T-cell–spective cohort study, we investigated the association infiltrated tumors were 0.63 (0.42–0.94; Ptrend ¼ 0.01) between calcium intake and colorectal cancer risk and 0.89 (0.58–1.35; Ptrend ¼ 0.20) for CD3þ; according to tumor immunity status to provide addi-0.58 (0.39–0.87; Ptrend ¼ 0.006) and 1.04 (0.69–tional insights into the role of calcium in colorectal 1.58; Ptrend ¼ 0.54) for CD45ROþ; and 0.56 (0.36–carcinogenesis. The densities of tumor-infiltrating 0.85; Ptrend ¼ 0.006) and 1.10 (0.72–1.67; Ptrend ¼ T-cell subsets [CD3þ, CD8þ, CD45RO (PTPRC)þ, or 0.47) for FOXP3þ, although the differences by sub-FOXP3þ cell] were assessed using IHC and computer-types defined by T-cell density were not statistically assisted image analysis in 736 cancer cases that devel-significant. These potential differential associations oped among 136,249 individuals in two cohorts. HRs generally appeared consistent regardless of sex, source and 95% confidence intervals (CI) were calculated of calcium intake, tumor location, and tumor micro-using Cox proportional hazards regression. Total cal-satellite instability status. Our findings suggest a pos-cium intake was associated with a multivariable HR of sible role of calcium in cancer immunoprevention via 0.55 (comparing 1,200 vs. <600 mg/day; 95% CI, modulation of T-cell function.

AB - Calcium intake has been associated with a lower risk 0.36–0.84; Ptrend ¼ 0.002) for CD8þ T-cell–low but not of colorectal cancer. Calcium signaling may enhance for CD8þ T-cell–high tumors (HR ¼ 1.02; 95% CI, T-cell proliferation and differentiation, and contribute 0.67–1.55; Ptrend ¼ 0.47). Similarly, the corresponding to T-cell–mediated antitumor immunity. In this pro-HRs (95% CIs) for calcium for low versus high T-cell–spective cohort study, we investigated the association infiltrated tumors were 0.63 (0.42–0.94; Ptrend ¼ 0.01) between calcium intake and colorectal cancer risk and 0.89 (0.58–1.35; Ptrend ¼ 0.20) for CD3þ; according to tumor immunity status to provide addi-0.58 (0.39–0.87; Ptrend ¼ 0.006) and 1.04 (0.69–tional insights into the role of calcium in colorectal 1.58; Ptrend ¼ 0.54) for CD45ROþ; and 0.56 (0.36–carcinogenesis. The densities of tumor-infiltrating 0.85; Ptrend ¼ 0.006) and 1.10 (0.72–1.67; Ptrend ¼ T-cell subsets [CD3þ, CD8þ, CD45RO (PTPRC)þ, or 0.47) for FOXP3þ, although the differences by sub-FOXP3þ cell] were assessed using IHC and computer-types defined by T-cell density were not statistically assisted image analysis in 736 cancer cases that devel-significant. These potential differential associations oped among 136,249 individuals in two cohorts. HRs generally appeared consistent regardless of sex, source and 95% confidence intervals (CI) were calculated of calcium intake, tumor location, and tumor micro-using Cox proportional hazards regression. Total cal-satellite instability status. Our findings suggest a pos-cium intake was associated with a multivariable HR of sible role of calcium in cancer immunoprevention via 0.55 (comparing 1,200 vs. <600 mg/day; 95% CI, modulation of T-cell function.

UR - http://www.scopus.com/inward/record.url?scp=85065511115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065511115&partnerID=8YFLogxK

U2 - 10.1158/1940-6207.CAPR-18-0279

DO - 10.1158/1940-6207.CAPR-18-0279

M3 - Article

VL - 12

SP - 283

EP - 293

JO - Cancer Prevention Research

JF - Cancer Prevention Research

SN - 1940-6207

IS - 5

ER -