Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata

Ikuma Shiota, Arihiro Iwasaki, Shimpei Sumimoto, Hiroshi Tomoda, Kiyotake Suenaga

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A new polyketide with a cis-fused decalin ring scaffold, caldorin, was isolated from the marine cyanobacterium Caldora penicillata. The gross structure and relative configuration were elucidated by spectroscopic analyses. We also clarified that caldorin is a weak SOAT inhibitor and moderate osteoblast differentiation inhibitor. On the other hand, caldorin did not exhibit cytotoxicity against either HeLa or HL60 cells.

Original languageEnglish
Pages (from-to)1261-1263
Number of pages3
JournalTetrahedron Letters
Volume59
Issue number13
DOIs
Publication statusPublished - 2018 Mar 28

Keywords

  • Caldora penicillata
  • Marine cyanobacteria
  • Natural products isolation
  • Polyketide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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