Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata

Ikuma Shiota, Arihiro Iwasaki, Shimpei Sumimoto, Hiroshi Tomoda, Kiyotake Suenaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A new polyketide with a cis-fused decalin ring scaffold, caldorin, was isolated from the marine cyanobacterium Caldora penicillata. The gross structure and relative configuration were elucidated by spectroscopic analyses. We also clarified that caldorin is a weak SOAT inhibitor and moderate osteoblast differentiation inhibitor. On the other hand, caldorin did not exhibit cytotoxicity against either HeLa or HL60 cells.

Original languageEnglish
Pages (from-to)1261-1263
Number of pages3
JournalTetrahedron Letters
Volume59
Issue number13
DOIs
Publication statusPublished - 2018 Mar 28

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Polyketides
HL-60 Cells
Osteoblasts
Cyanobacteria
Cytotoxicity
HeLa Cells
Scaffolds
decalin

Keywords

  • Caldora penicillata
  • Marine cyanobacteria
  • Natural products isolation
  • Polyketide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata. / Shiota, Ikuma; Iwasaki, Arihiro; Sumimoto, Shimpei; Tomoda, Hiroshi; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 59, No. 13, 28.03.2018, p. 1261-1263.

Research output: Contribution to journalArticle

Shiota, Ikuma ; Iwasaki, Arihiro ; Sumimoto, Shimpei ; Tomoda, Hiroshi ; Suenaga, Kiyotake. / Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata. In: Tetrahedron Letters. 2018 ; Vol. 59, No. 13. pp. 1261-1263.
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