Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Motoko Kawashima, Yoko Ozawa, Ken Shinmura, Takaaki Inaba, Shigeru Nakamura, Tetsuya Kawakita, Mitsuhiro Watanabe, Kazuo Tsubota

Research output: Contribution to journalArticle

16 Citations (Scopus)


The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.

Original languageEnglish
Pages (from-to)1096-1100
Number of pages5
JournalExperimental Gerontology
Issue number10
Publication statusPublished - 2013 Oct 1


  • Calorie restriction
  • Calorie restriction mimetics
  • Cataract
  • Dry eye
  • Retinal disease

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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