Can early aggressive administration of fresh frozen plasma improve outcomes in patients with severe blunt trauma? - A report by the Japanese Association for the Surgery of Trauma

Akiyoshi Hagiwara, Shigeki Kushimoto, Hiroshi Kato, Junichi Sasaki, Hiroshi Ogura, Tetsuya Matsuoka, Toshifumi Uejima, Mineji Hayakawa, Munekazu Takeda, Naoyuki Kaneko, Daizoh Saitoh, Yasuhiro Otomo, Hiroyuki Yokota, Teruo Sakamoto, Hiroshi Tanaka, Atsushi Shiraishi, Naoto Morimura, Hiroyasu Ishikura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: This study investigated the effect of a high ratio of fresh frozen plasma (FFP) to red blood cells (RBCs) within the first 6 and 24h after admission on mortality in patients with severe, blunt trauma. Methods: This retrospective observational study included 189 blunt trauma patients with an Injury Severity Score (ISS) ≥16 requiring RBC transfusions within the first 24h. Receiver operating characteristic (ROC) curve analysis was performed to calculate cut-off values of the FFP/RBC ratio for outcome. The patients were then divided into two groups according to the cut-off value. Patient survival was compared between groups using propensity score matching (PSM). Results: The area under the ROC curve was 0.57, and the FFP/RBC ratio was 1.0 at maximum sensitivity (0.57) and specificity (0.67). All patients were then divided into two groups (FFP/RBC ratio ≥1 or

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalShock
Volume45
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Erythrocytes
Wounds and Injuries
ROC Curve
Erythrocyte Transfusion
Propensity Score
Injury Severity Score
Observational Studies
Retrospective Studies
Sensitivity and Specificity
Survival
Mortality

Keywords

  • Blood transfusion
  • blunt trauma
  • FFP
  • fresh frozen plasma
  • propensity score

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Can early aggressive administration of fresh frozen plasma improve outcomes in patients with severe blunt trauma? - A report by the Japanese Association for the Surgery of Trauma. / Hagiwara, Akiyoshi; Kushimoto, Shigeki; Kato, Hiroshi; Sasaki, Junichi; Ogura, Hiroshi; Matsuoka, Tetsuya; Uejima, Toshifumi; Hayakawa, Mineji; Takeda, Munekazu; Kaneko, Naoyuki; Saitoh, Daizoh; Otomo, Yasuhiro; Yokota, Hiroyuki; Sakamoto, Teruo; Tanaka, Hiroshi; Shiraishi, Atsushi; Morimura, Naoto; Ishikura, Hiroyasu.

In: Shock, Vol. 45, No. 5, 01.05.2016, p. 495-501.

Research output: Contribution to journalArticle

Hagiwara, A, Kushimoto, S, Kato, H, Sasaki, J, Ogura, H, Matsuoka, T, Uejima, T, Hayakawa, M, Takeda, M, Kaneko, N, Saitoh, D, Otomo, Y, Yokota, H, Sakamoto, T, Tanaka, H, Shiraishi, A, Morimura, N & Ishikura, H 2016, 'Can early aggressive administration of fresh frozen plasma improve outcomes in patients with severe blunt trauma? - A report by the Japanese Association for the Surgery of Trauma', Shock, vol. 45, no. 5, pp. 495-501. https://doi.org/10.1097/SHK.0000000000000536
Hagiwara, Akiyoshi ; Kushimoto, Shigeki ; Kato, Hiroshi ; Sasaki, Junichi ; Ogura, Hiroshi ; Matsuoka, Tetsuya ; Uejima, Toshifumi ; Hayakawa, Mineji ; Takeda, Munekazu ; Kaneko, Naoyuki ; Saitoh, Daizoh ; Otomo, Yasuhiro ; Yokota, Hiroyuki ; Sakamoto, Teruo ; Tanaka, Hiroshi ; Shiraishi, Atsushi ; Morimura, Naoto ; Ishikura, Hiroyasu. / Can early aggressive administration of fresh frozen plasma improve outcomes in patients with severe blunt trauma? - A report by the Japanese Association for the Surgery of Trauma. In: Shock. 2016 ; Vol. 45, No. 5. pp. 495-501.
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