Can Helicobacter pylori-associated dyspepsia be categorized as functional dyspepsia?

Hidekazu Suzuki, Toshihiro Nishizawa, Toshifumi Hibi

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)

Abstract

Evidence for an association between H. pylori and functional dyspepsia (FD) is uncertain. In the present review, we focused the special relevance of H. pylori infection to the development dyspepsia from the aspects of pathogensis, clinical efficacy of eradication of H. pylori in the West and in the East. Although clinical trials conducted to evaluate the efficacy of H. pylori eradication treatment for FD, including non-ulcer dyspepsia (NUD), have yielded conflicting results, it is quite clear that H. pylori eradication treatment is effective at least in a subset of FD patients. In contrast to the previous results obtained in studies of Western populations, the result of a double-blind, randomized, placebo-controlled trial conducted in a Singapore suggests that patients with FD could benefit from H. pylori eradication therapy, with as much as a 13-fold increase in the chance of symptom resolution. Especially in Asia, H. pylori should not be overlooked when considering the pathophysiology of FD. H. pylori-associated dyspepsia might be dealt as a different disease entity from FD.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume26
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • Acid
  • Asia
  • Eradication
  • Functional dyspepsia
  • Ghrelin
  • Helicobacter pylori
  • Meta-analysis
  • MicroRNA

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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