Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors

K. Kikuchi, M. Ueda, Yuukou Kitagawa, N. Ando, O. Abe

Research output: Contribution to journalArticle

Abstract

We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patients with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.

Original languageEnglish
Pages (from-to)1090-1093
Number of pages4
JournalNippon Geka Gakkai zasshi
Volume92
Issue number9
Publication statusPublished - 1991 Sep

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Oncogenes
Neoplasm Metastasis
Recurrence
Neoplasms
Gene Amplification
Esophageal Neoplasms
Stomach Neoplasms
Survival Rate
Biomarkers
Breast Neoplasms
Gene Expression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors. / Kikuchi, K.; Ueda, M.; Kitagawa, Yuukou; Ando, N.; Abe, O.

In: Nippon Geka Gakkai zasshi, Vol. 92, No. 9, 09.1991, p. 1090-1093.

Research output: Contribution to journalArticle

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