Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors

K. Kikuchi, M. Ueda, Y. Kitagawa, N. Ando, O. Abe

Research output: Contribution to journalArticle

Abstract

We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patients with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.

Original languageEnglish
Pages (from-to)1090-1093
Number of pages4
JournalNippon Geka Gakkai zasshi
Volume92
Issue number9
Publication statusPublished - 1991 Sep

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Cancer metastasis and recurrence from the standpoint of amplification and expression of oncogenes in human malignant tumors'. Together they form a unique fingerprint.

  • Cite this