Abstract
We investigated the amplification and expression of oncogenes in human malignant tumors. The survival rates of patients with c-erbB, c-erbB-2, and int-2 oncogene amplification/expression were significantly lower than those of the patients without gene amplification/expression. Many distant organ metastases were observed in esophageal cancer patients with int-2 amplification, in gastric cancer patients with c-erbB-2 over-expression, and in breast cancer patients with int-2 and c-erbB-2 amplification. These results suggest that the amplification/expression of these oncogenes may serve as good markers for determining the biological malignancy of cancers.
| Original language | English |
|---|---|
| Pages (from-to) | 1090-1093 |
| Number of pages | 4 |
| Journal | Nippon Geka Gakkai zasshi |
| Volume | 92 |
| Issue number | 9 |
| Publication status | Published - 1991 Sept |
ASJC Scopus subject areas
- Medicine(all)
