Candidate biomarkers for genetic and clinic opathological diagnosis of endometrial cancer

Kouji Banno, Yuya Nogami, Iori Kisu, Megumi Yanokura, Kiyoko Umene, Kenta Masuda, Yusuke Kobayashi, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.

Original languageEnglish
Pages (from-to)12123-12137
Number of pages15
JournalInternational journal of molecular sciences
Volume14
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • CA125
  • CHFR
  • DNA hypermethylation
  • Endometrial cancer
  • K-ras
  • Lynch syndrome
  • MSH6
  • Microsatellite instability
  • PTEN
  • microRNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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