Candidate biomarkers for genetic and clinic opathological diagnosis of endometrial cancer

Kouji Banno, Yuya Nogami, Iori Kisu, Megumi Yanokura, Kiyoko Umene, Kenta Masuda, Yusuke Kobayashi, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.

Original languageEnglish
Pages (from-to)12123-12137
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume14
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Fingerprint

biomarkers
Biomarkers
Endometrial Neoplasms
cancer
Molecular biology
MicroRNAs
Tumors
molecular biology
Planning
mutations
Early Detection of Cancer
Epigenomics
Blood Vessels
planning
Molecular Biology
therapy
tumors
Mutation
predictions
Neoplasms

Keywords

  • CA125
  • CHFR
  • DNA hypermethylation
  • Endometrial cancer
  • K-ras
  • Lynch syndrome
  • microRNA
  • Microsatellite instability
  • MSH6
  • PTEN

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Candidate biomarkers for genetic and clinic opathological diagnosis of endometrial cancer. / Banno, Kouji; Nogami, Yuya; Kisu, Iori; Yanokura, Megumi; Umene, Kiyoko; Masuda, Kenta; Kobayashi, Yusuke; Yamagami, Wataru; Susumu, Nobuyuki; Aoki, Daisuke.

In: International Journal of Molecular Sciences, Vol. 14, No. 6, 06.2013, p. 12123-12137.

Research output: Contribution to journalArticle

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