Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma

Michiie Sakamoto, Taisuke Mori, Yohei Masugi, Kathryn Effendi, Irie Rie, Wenlin Du

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. HCC occurs mainly in chronically diseased livers, e.g. following hepatitis B and C infection. These high-risk patients are closely followed up, and increasing numbers of small equivocal lesions are detected by imaging diagnosis. They are now widely recognized as precursor or early-stage HCCs and are classified as dysplastic nodule or early HCC. These lesions lack typical imaging and histology of ordinary HCC and do not show elevated serum markers of α-fetoprotein and PIVKA-II, for example. Molecular analysis of these lesions would help to develop molecular markers for objective histological diagnosis of early HCC and possibly new serum markers for early detection of HCC. It has been reported that HSP70, CAP2, glypican 3 and glutamine synthetase could serve as molecular markers for early HCC. Further analysis is expected to evaluate their usefulness in routine pathological diagnosis including biopsy diagnosis and also as serum markers for early detection of HCC.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalIntervirology
Volume51
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2008 Jun 1

Keywords

  • CAP2
  • Early hepatocellular carcinoma
  • Expression profile
  • HSP70
  • Molecular markers
  • Precancerous lesions

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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