Capacity-limited elimination of cefmetazole in rat

K. Yamaoka, Yusuke Tanigawara, T. Nakagawa, T. Uno

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Elimination kinetics of cefmetazole (CMZ) in the rat is studied with changing the dosing amount (D). The normalized area under plasma concentration-time curve (AUC/D) and the mean residence time (MRT) increase with increasing amount of i.v. dose of CMZ. These increases prove the capacity-limited elimination of CMZ without regard to any pharmacokinetic model. The apparent steady-state volume of distribution (Vass) which is defined by D β MRT/AUC is almost independent of D. The simultaneous multi-lines fitting using time course curves following different doses is also attempted to determine the pharmacokinetic model by the application of the minimum AIC estimation (MAICE). AIC, consequently, shows the minimum for the two-compartment model with the Michaelis-Menten elimination. The Yss estimated from this model is about 450 ml/kg which agrees with Vass estimated by moment analysis.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume10
Issue number4
DOIs
Publication statusPublished - 1982
Externally publishedYes

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Cefmetazole
Area Under Curve
Pharmacokinetics

Keywords

  • AIC
  • capacity limited elimination
  • cefmetazole
  • moment analysis
  • SALS
  • V

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Capacity-limited elimination of cefmetazole in rat. / Yamaoka, K.; Tanigawara, Yusuke; Nakagawa, T.; Uno, T.

In: International Journal of Pharmaceutics, Vol. 10, No. 4, 1982, p. 291-300.

Research output: Contribution to journalArticle

Yamaoka, K. ; Tanigawara, Yusuke ; Nakagawa, T. ; Uno, T. / Capacity-limited elimination of cefmetazole in rat. In: International Journal of Pharmaceutics. 1982 ; Vol. 10, No. 4. pp. 291-300.
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