Capillary model of crystal microchannel for red blood cell deformability measurement

Kosuke Tsukada, Eiichi Sekizuka, Chikara Oshio, Takahiro Nagai, Haruyuki Minamitani

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

To measure red blood cell (RBC) deformability in vitro, we used microchannels on a crystal substrate as a capillary model. We observed axisymmetry deformed RBCs to estimate their deformability and decided deformability index directly from RBCs themselves. The flowing RBCs in 200 folds through microscopy were recorded with an image-intensified high speed video camera-system. This system allowed us to record individual RBC images clearly. We confirmed that the crystal microchannel is a valuable tool for RBC deformability measurement. Microangiopathy is a characteristic complication of diabetes mellitus. The decrease of RBC deformability is thought to cause this complication. In order to identify the deference in RBCs deformability between normal and diabetic RBCs. We could confirm that deformability of diabetic RBCs were much lower than normal ones, and this result suggests a possibility of serious damage in diabetic microcirculation.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages2375-2376
Number of pages2
Volume6
Publication statusPublished - 1997
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: 1997 Oct 301997 Nov 2

Other

OtherProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityChicago, IL, USA
Period97/10/3097/11/2

Fingerprint

Formability
Microchannels
Blood
Cells
Crystals
Microcirculation
High speed cameras
Video cameras
Medical problems
Microscopic examination
Substrates

ASJC Scopus subject areas

  • Bioengineering

Cite this

Tsukada, K., Sekizuka, E., Oshio, C., Nagai, T., & Minamitani, H. (1997). Capillary model of crystal microchannel for red blood cell deformability measurement. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 6, pp. 2375-2376). IEEE.

Capillary model of crystal microchannel for red blood cell deformability measurement. / Tsukada, Kosuke; Sekizuka, Eiichi; Oshio, Chikara; Nagai, Takahiro; Minamitani, Haruyuki.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 6 IEEE, 1997. p. 2375-2376.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tsukada, K, Sekizuka, E, Oshio, C, Nagai, T & Minamitani, H 1997, Capillary model of crystal microchannel for red blood cell deformability measurement. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 6, IEEE, pp. 2375-2376, Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, USA, 97/10/30.
Tsukada K, Sekizuka E, Oshio C, Nagai T, Minamitani H. Capillary model of crystal microchannel for red blood cell deformability measurement. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 6. IEEE. 1997. p. 2375-2376
Tsukada, Kosuke ; Sekizuka, Eiichi ; Oshio, Chikara ; Nagai, Takahiro ; Minamitani, Haruyuki. / Capillary model of crystal microchannel for red blood cell deformability measurement. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 6 IEEE, 1997. pp. 2375-2376
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