Capillary model of crystal microchannel for red blood cell deformability measurement

Kosuke Tsukada, Eiichi Sekizuka, Chikara Oshio, Takahiro Nagai, Haruyuki Minamitani

Research output: Contribution to journalConference article

1 Citation (Scopus)

Abstract

To measure red blood cell (RBC) deformability in vitro, we used microchannels on a crystal substrate as a capillary model. We observed axisymmetry deformed RBCs to estimate their deformability and decided deformability index directly from RBCs themselves. The flowing RBCs in 200 folds through microscopy were recorded with an image-intensified high speed video camera-system. This system allowed us to record individual RBC images clearly. We confirmed that the crystal microchannel is a valuable tool for RBC deformability measurement. Microangiopathy is a characteristic complication of diabetes mellitus. The decrease of RBC deformability is thought to cause this complication. In order to identify the deference in RBCs deformability between normal and diabetic RBCs. We could confirm that deformability of diabetic RBCs were much lower than normal ones, and this result suggests a possibility of serious damage in diabetic microcirculation.

Original languageEnglish
Pages (from-to)2375-2376
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume6
Publication statusPublished - 1997 Dec 1
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: 1997 Oct 301997 Nov 2

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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