Carbohydrate-modulated DNA photocleavage: Design, synthesis, and evaluation of novel glycosyl anthraquinones

Kazunobu Toshima, Yutaka Maeda, Hiromi Ouchi, Akira Asai, Shuichi Matsumura

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2163-2165
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number19
DOIs
Publication statusPublished - 2000 Oct 2

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Anthraquinones
Ultraviolet Rays
Cytotoxicity
HeLa Cells
Ultraviolet radiation
Carbohydrates
Irradiation
Wavelength
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Carbohydrate-modulated DNA photocleavage : Design, synthesis, and evaluation of novel glycosyl anthraquinones. / Toshima, Kazunobu; Maeda, Yutaka; Ouchi, Hiromi; Asai, Akira; Matsumura, Shuichi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 19, 02.10.2000, p. 2163-2165.

Research output: Contribution to journalArticle

Toshima, Kazunobu ; Maeda, Yutaka ; Ouchi, Hiromi ; Asai, Akira ; Matsumura, Shuichi. / Carbohydrate-modulated DNA photocleavage : Design, synthesis, and evaluation of novel glycosyl anthraquinones. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 19. pp. 2163-2165.
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