Carbohydrate-modulated DNA photocleavage: Design, synthesis, and evaluation of novel glycosyl anthraquinones

Kazunobu Toshima, Yutaka Maeda, Hiromi Ouchi, Akira Asai, Shuichi Matsumura

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2163-2165
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number19
DOIs
Publication statusPublished - 2000 Oct 2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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