Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion

M. Suematsu, S. Kashiwagi, T. Sano, N. Goda, Y. Shinoda, Y. Ishimura

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Carbon monoxide (CO) generated by heme oxygenase has recently been considered a neural messenger in brain. This observation prompted us to investigate whether CO participates in vascular regulation in the liver, another organ with high levels of heme oxygenase activity. In isolated perfused rat liver, submicromolar levels of CO were detectable in the effluent and were able to be suppressed by the administration of Zn protoporphyrin IX (1 μM), a potent inhibitor of heme oxygenase. Furthermore, zinc protoporphyrin IX (1 μM) promoted an increase in the perfusion pressure under the constant flow conditions. These changes were reversed by adding CO (2 μM) or a cGMP analogue 8-bromo-cGMP (1 μM) in the perfusate. The present findings indicate that CO can function as an endogenous modulator of vascular perfusion in the liver.

Original languageEnglish
Pages (from-to)1333-1337
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume205
Issue number2
DOIs
Publication statusPublished - 1994 Dec 15

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Carbon Monoxide
Modulators
Blood Vessels
Heme Oxygenase (Decyclizing)
Perfusion
Liver
Rats
Effluents
Brain
Pressure

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

Suematsu, M., Kashiwagi, S., Sano, T., Goda, N., Shinoda, Y., & Ishimura, Y. (1994). Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion. Biochemical and Biophysical Research Communications, 205(2), 1333-1337. https://doi.org/10.1006/bbrc.1994.2811

Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion. / Suematsu, M.; Kashiwagi, S.; Sano, T.; Goda, N.; Shinoda, Y.; Ishimura, Y.

In: Biochemical and Biophysical Research Communications, Vol. 205, No. 2, 15.12.1994, p. 1333-1337.

Research output: Contribution to journalArticle

Suematsu, M, Kashiwagi, S, Sano, T, Goda, N, Shinoda, Y & Ishimura, Y 1994, 'Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion', Biochemical and Biophysical Research Communications, vol. 205, no. 2, pp. 1333-1337. https://doi.org/10.1006/bbrc.1994.2811
Suematsu, M. ; Kashiwagi, S. ; Sano, T. ; Goda, N. ; Shinoda, Y. ; Ishimura, Y. / Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 205, No. 2. pp. 1333-1337.
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