Carbon monoxide-dependent regulation of microvascular function: One gas regulates another

Makoto Suematsu, Mayumi Kajimura, Yasuaki Kabe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Carbon monoxide (CO) is a gaseous product generated by heme oxygenase (HO). Because of its nature to bind to the metal-centered prosthetic groups, the gas might bind to multiple target proteins to regulate varied biological functions. Previous studies revealed that stress-inducible levels of CO from HO-1 modulate function of different heme proteins or enzymes through binding to their prosthetic ferrous heme to regulate biological function of cells and organs including hepatobiliary systems. On the other hand, CO derived from constitutive HO-2 appeared to play house-keeping roles for microvascular perfusion or cellular homeostasis: such CO-directed target macromolecules include soluble guanylate cyclase, cytochromes P450 and NO synthase. Our recent studies revealed roles of cystathionine β-synthase in vivo for a novel CO-sensitive regulator of metabolic system that is a determinant of endogenous H2S, another gaseous mediator. This chapter reviews the intriguing networks of metabolic regulatory mechanisms constituted by different gaseous mediators and their medical implications.

Original languageEnglish
Title of host publicationFree Radical Biology in Digestive Diseases
PublisherS. Karger AG
Pages79-84
Number of pages6
Volume29
ISBN (Print)9783805596107, 9783805596091
DOIs
Publication statusPublished - 2010 Dec 21

Fingerprint

Carbon Monoxide
carbon monoxide
Gases
Gasotransmitters
gases
Prosthetics
Cystathionine
Hemeproteins
proteins
homeostasis
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Guanylate Cyclase
cytochromes
regulators
Metabolic Networks and Pathways
Macromolecules
Heme
macromolecules
determinants

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Suematsu, M., Kajimura, M., & Kabe, Y. (2010). Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. In Free Radical Biology in Digestive Diseases (Vol. 29, pp. 79-84). S. Karger AG. https://doi.org/10.1159/000319951

Carbon monoxide-dependent regulation of microvascular function : One gas regulates another. / Suematsu, Makoto; Kajimura, Mayumi; Kabe, Yasuaki.

Free Radical Biology in Digestive Diseases. Vol. 29 S. Karger AG, 2010. p. 79-84.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suematsu, M, Kajimura, M & Kabe, Y 2010, Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. in Free Radical Biology in Digestive Diseases. vol. 29, S. Karger AG, pp. 79-84. https://doi.org/10.1159/000319951
Suematsu M, Kajimura M, Kabe Y. Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. In Free Radical Biology in Digestive Diseases. Vol. 29. S. Karger AG. 2010. p. 79-84 https://doi.org/10.1159/000319951
Suematsu, Makoto ; Kajimura, Mayumi ; Kabe, Yasuaki. / Carbon monoxide-dependent regulation of microvascular function : One gas regulates another. Free Radical Biology in Digestive Diseases. Vol. 29 S. Karger AG, 2010. pp. 79-84
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