Carbon monoxide-dependent regulation of microvascular function: One gas regulates another

Makoto Suematsu, Mayumi Kajimura, Yasuaki Kabe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Carbon monoxide (CO) is a gaseous product generated by heme oxygenase (HO). Because of its nature to bind to the metal-centered prosthetic groups, the gas might bind to multiple target proteins to regulate varied biological functions. Previous studies revealed that stress-inducible levels of CO from HO-1 modulate function of different heme proteins or enzymes through binding to their prosthetic ferrous heme to regulate biological function of cells and organs including hepatobiliary systems. On the other hand, CO derived from constitutive HO-2 appeared to play house-keeping roles for microvascular perfusion or cellular homeostasis: such CO-directed target macromolecules include soluble guanylate cyclase, cytochromes P450 and NO synthase. Our recent studies revealed roles of cystathionine β-synthase in vivo for a novel CO-sensitive regulator of metabolic system that is a determinant of endogenous H 2S, another gaseous mediator. This chapter reviews the intriguing networks of metabolic regulatory mechanisms constituted by different gaseous mediators and their medical implications.

Original languageEnglish
Title of host publicationFrontiers of Gastrointestinal Research
Pages79-84
Number of pages6
Volume29
DOIs
Publication statusPublished - 2010 Dec

Publication series

NameFrontiers of Gastrointestinal Research
Volume29
ISSN (Print)03020665

Fingerprint

Carbon Monoxide
Gases
Gasotransmitters
Cystathionine
Hemeproteins
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Metabolic Networks and Pathways
Heme
Nitric Oxide Synthase
Cytochrome P-450 Enzyme System
Homeostasis
Perfusion
Metals
Enzymes
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Suematsu, M., Kajimura, M., & Kabe, Y. (2010). Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. In Frontiers of Gastrointestinal Research (Vol. 29, pp. 79-84). (Frontiers of Gastrointestinal Research; Vol. 29). https://doi.org/10.1159/0003200516

Carbon monoxide-dependent regulation of microvascular function : One gas regulates another. / Suematsu, Makoto; Kajimura, Mayumi; Kabe, Yasuaki.

Frontiers of Gastrointestinal Research. Vol. 29 2010. p. 79-84 (Frontiers of Gastrointestinal Research; Vol. 29).

Research output: Chapter in Book/Report/Conference proceedingChapter

Suematsu, M, Kajimura, M & Kabe, Y 2010, Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. in Frontiers of Gastrointestinal Research. vol. 29, Frontiers of Gastrointestinal Research, vol. 29, pp. 79-84. https://doi.org/10.1159/0003200516
Suematsu M, Kajimura M, Kabe Y. Carbon monoxide-dependent regulation of microvascular function: One gas regulates another. In Frontiers of Gastrointestinal Research. Vol. 29. 2010. p. 79-84. (Frontiers of Gastrointestinal Research). https://doi.org/10.1159/0003200516
Suematsu, Makoto ; Kajimura, Mayumi ; Kabe, Yasuaki. / Carbon monoxide-dependent regulation of microvascular function : One gas regulates another. Frontiers of Gastrointestinal Research. Vol. 29 2010. pp. 79-84 (Frontiers of Gastrointestinal Research).
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