Carcinogenic mechanisms of endometrial cancer: Involvement of genetics and epigenetics

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Endometrial cancer is increasing worldwide and the number of patients with this disease is likely to continue to grow, including younger patients. Many endometrial cancers show estrogen-dependent proliferation, but the carcinogenic mechanisms are unknown or not completely explained beyond mutations of single oncogenes and tumor suppressor genes. Possible carcinogenic mechanisms include imbalance between endometrial proliferation by unopposed estrogen and the mismatch repair (MMR) system; hypermethylation of the MMR gene hMLH1; mutation of PTEN, β-catenin and K-ras genes in type I endometrial cancer and of HER-2/neu and p53 genes in type II endometrial cancer; hypermethylation of SPRY2, RASSF1A, RSK4, CHFR and CDH1; and methylation of tumor suppressor microRNAs, including miR-124, miR-126, miR-137, miR-491, miR-129-2 and miR-152. Thus, it is likely that the carcinogenic mechanisms of endometrial cancer involve both genetic and epigenetic changes. Mutations and methylation of MMR genes induce various oncogenic changes that cause carcinogenesis, and both MMR mutation in germ cells and methylation patterns may be inherited over generations and cause familial tumorigenesis. Determination of the detailed carcinogenic mechanisms will be useful for prevention and diagnosis of endometrial cancer, risk assessment, and development of new treatment strategies targeting MMR genes.

Original languageEnglish
Pages (from-to)1957-1967
Number of pages11
JournalJournal of Obstetrics and Gynaecology Research
Volume40
Issue number8
DOIs
Publication statusPublished - 2014 Aug

Keywords

  • DNA hypermethylation
  • DNA mismatch repair
  • endometrial cancer
  • epigenetics
  • genetics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Carcinogenic mechanisms of endometrial cancer: Involvement of genetics and epigenetics'. Together they form a unique fingerprint.

  • Cite this